Adipose tissue‐derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway

2018 ◽  
Vol 120 (3) ◽  
pp. 4057-4064 ◽  
Author(s):  
Chi‐Yung Chai ◽  
Junlong Song ◽  
Zhenwei Tan ◽  
I‐Chun Tai ◽  
Chaoying Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
P38 Mapk ◽  
Hypertrophic Scar ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

Gold Nanoparticles Promote Osteogenic Differentiation of Mesenchymal Stem Cells through p38 MAPK Pathway

ACS Nano ◽  
2010 ◽  
Vol 4 (11) ◽  
pp. 6439-6448 ◽  
Author(s):  
Changqing Yi ◽  
Dandan Liu ◽  
Chi-Chun Fong ◽  
Jinchao Zhang ◽  
Mengsu Yang
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

scholarly journals Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway

2021 ◽  
Vol 218 (6) ◽  
Author(s):  
Tong Wu ◽  
Qinhui Liu ◽  
Yanping Li ◽  
Hong Li ◽  
Lei Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Obese Mouse ◽  
Diet Induced Obesity ◽  
P38 Mapk Pathway ◽  
Beige Adipocytes ◽  
Adipose Inflammation

Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy to combat obesity. We identified that mesencephalic astrocyte–derived neurotrophic factor (Manf) is a feeding-induced hepatokine. Liver-specific Manf overexpression protected mice against high-fat diet–induced obesity and promoted browning of inguinal subcutaneous WAT (iWAT). Manf overexpression in liver was also associated with decreased adipose inflammation and improved insulin sensitivity and hepatic steatosis. Mechanistically, Manf could directly promote browning of white adipocytes via the p38 MAPK pathway. Blockade of p38 MAPK abolished Manf-induced browning. Consistently, liver-specific Manf knockout mice showed impaired iWAT browning and exacerbated diet-induced obesity, insulin resistance, and hepatic steatosis. Recombinant Manf reduced obesity and improved insulin resistance in both diet-induced and genetic obese mouse models. Finally, we showed that circulating Manf level was positively correlated with BMI in humans. This study reveals the crucial role of Manf in regulating thermogenesis in adipose tissue, representing a potential therapeutic target for obesity and related metabolic disorders.

scholarly journals Inhibition of actin polymerization decreases osteogeneic differentiation of mesenchymal stem cells through p38 MAPK pathway

2013 ◽  
Vol 20 (1) ◽  
pp. 71 ◽  
Author(s):  
Himangshu Sonowal ◽  
Atul Kumar ◽  
Jina Bhattacharyya ◽  
Pabitra Gogoi ◽  
Bithiah Jaganathan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
P38 Mapk ◽  
Actin Polymerization ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

scholarly journals p38 MAPK pathway is essential for self-renewal of mouse male germline stem cells (mGSCs)

2016 ◽  
Vol 50 (1) ◽  
pp. e12314 ◽  
Author(s):  
Zhiwei Niu ◽  
Hailong Mu ◽  
Haijing Zhu ◽  
Jiang Wu ◽  
Jinlian Hua
Keyword(s):  
Stem Cells ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Male Germline ◽  
P38 Mapk Pathway ◽  
Male Germline Stem Cells

Role of the p38 MAPK Pathway in Induction of iNOS Expression in Human Leukocytes

2008 ◽  
Vol 56 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Ewa Jablonska ◽  
Wioletta Ratajczak ◽  
Jakub Jablonski
Keyword(s):  
P38 Mapk ◽  
Mapk Pathway ◽  
Inos Expression ◽  
Human Leukocytes ◽  
P38 Mapk Pathway

Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway

2021 ◽  
Author(s):  
Lingfan Xiong ◽  
Wenhao Guo ◽  
Yong Yang ◽  
Danping Gao ◽  
Jun Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway
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