Nobiletin suppresses high‐glucose–induced inflammation and ECM accumulation in human mesangial cells through STAT3/NF‐κB pathway

2018 ◽  
Vol 120 (3) ◽  
pp. 3467-3473 ◽  
Author(s):  
Zhenzhou Liu ◽  
Yanru Han ◽  
Fucheng Zhao ◽  
Zhenxia Zhao ◽  
Junlei Tian ◽  
...  
Keyword(s):  
High Glucose ◽  
Mesangial Cells ◽  
Human Mesangial Cells

scholarly journals High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells

Renal Failure ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 762-769
Author(s):  
Fumeng Huang ◽  
Yuanxu Guo ◽  
Li Wang ◽  
Lanmei Jing ◽  
Zhao Chen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
High Glucose ◽  
Mesangial Cells ◽  
Human Mesangial Cells ◽  
Selenoprotein S ◽  
Tgf Β1

scholarly journals High glucose and hyperosmolality stimulate hepatocyte growth factor secretion from cultured human mesangial cells

Diabetologia ◽  
1994 ◽  
Vol 37 (5) ◽  
pp. 533-535 ◽  
Author(s):  
J. J. Couper ◽  
A. Ferrante ◽  
K. D. Littleford ◽  
R. T. L. Couper ◽  
T. Nakamura
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
High Glucose ◽  
Mesangial Cells ◽  
Human Mesangial Cells ◽  
Hepatocyte Growth ◽  
Factor Secretion ◽  
Growth Factor Secretion

scholarly journals Glucagon-like peptide-1 receptor pathway inhibits extracellular matrix production by mesangial cells through store-operated Ca2+ channel

2019 ◽  
Vol 244 (14) ◽  
pp. 1193-1201 ◽  
Author(s):  
Linjing Huang ◽  
Rong Ma ◽  
Tingting Lin ◽  
Sarika Chaudhari ◽  
Parisa Y Shotorbani ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
High Glucose ◽  
Protein Production ◽  
Matrix Protein ◽  
Mesangial Cells ◽  
Collagen Iv ◽  
Extracellular Matrix Protein ◽  
Human Mesangial Cells ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Glomerular mesangial cell is the major source of mesangial matrix. Our previous study demonstrated that store-operated Ca2+ channel signaling suppressed extracellular matrix protein production by mesangial cells. Recent studies demonstrated that glucagon-like peptide-1 receptor (GLP-1R) pathway had renoprotective effects. However, the underlying mechanism(s) remains unclear. The present study was aimed to determine if activation of GLP-1R decreased extracellular matrix protein production by mesangial cells through upregulation of store-operated Ca2+ function. Experiments were conducted in cultured human mesangial cells. Liraglutide and exendin 9–39 were used to activate and inhibit GLP-1R, respectively. Store-operated Ca2+ function was estimated by evaluating the SOC-mediated Ca2+ entry (SOCE). We found that liraglutide treatment reduced high glucose-stimulated production of fibronectin and collagen IV. The inhibitory effects of liraglutide were not observed in the presence of exendin 9–39. Exendin-4, another GLP-1R agonist also blunted high glucose-stimulated fibronectin and collagen IV production. Treatment of human mesangial cells with liraglutide for 24 h significantly attenuated the high glucose-induced reduction of Orai1 protein. Consistently, Ca2+ imaging experiments showed that the inhibition of high glucose on SOCE was significantly attenuated by liraglutide. However, in the presence of exendin 9–39, liraglutide failed to reverse the high glucose effect. Furthermore, liraglutide effects on fibronectin and collagen IV protein abundance were significantly attenuated by GSK-7975A, a selective blocker of store-operated Ca2+. Taken together, our findings suggest that GLP-1R signaling inhibited high glucose-induced extracellular matrix protein production in mesangial cells by restoring store-operated Ca2+ function. Impact statement Diabetic kidney disease continues to be a major challenge to health care system in the world. There are no known therapies currently available that can cure the disease. The present study provided compelling evidence that activation of GLP-1R inhibited extracellular matrix protein production by glomerular mesangial cells. We further showed that the beneficial effect of GLP-1R was attributed to upregulation of store-operated Ca2+ channel function. Therefore, we identified a novel mechanism contributing to the renal protective effects of GLP-1R pathway. Activation of GLP-1R pathway and/or store-operated Ca2+ channel signaling in MCs could be an option for patients with diabetic kidney disease.

A High Glucose Concentration Stimulates the Expression of Monocyte Chemotactic Peptide 1 in Human Mesangial Cells

Nephron ◽  
1998 ◽  
Vol 79 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Chun-Gyoo Ihm ◽  
Jae-Kyung Park ◽  
Seong-Pyo Hong ◽  
Tae-Won Lee ◽  
Byoung-Soo Cho ◽  
...  
Keyword(s):  
High Glucose ◽  
Glucose Concentration ◽  
Mesangial Cells ◽  
High Glucose Concentration ◽  
Chemotactic Peptide ◽  
Human Mesangial Cells

scholarly journals Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin synthesis in human mesangial cells

FEBS Letters ◽  
2008 ◽  
Vol 582 (23-24) ◽  
pp. 3484-3488 ◽  
Author(s):  
Yonghong Shi ◽  
Yanling Zhang ◽  
Chen Wang ◽  
Chunyang Du ◽  
Song Zhao ◽  
...  
Keyword(s):  
High Glucose ◽  
Mesangial Cells ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Human Mesangial Cells ◽  
Tgf Β1
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