Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA CILinc02

2018 ◽  
Vol 120 (3) ◽  
pp. 3331-3338 ◽  
Author(s):  
Jiapeng Zheng ◽  
Qiang Li
Keyword(s):  
Methylene Blue ◽  
Inflammatory Response ◽  
Long Chain

Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages

2014 ◽  
Vol 151 (1) ◽  
pp. 131-136 ◽  
Author(s):  
S. Montserrat-de la Paz ◽  
M.D. García-Giménez ◽  
M. Ángel-Martín ◽  
M.C. Pérez-Camino ◽  
A. Fernández Arche
Keyword(s):  
Inflammatory Response ◽  
Peritoneal Macrophages ◽  
Fatty Alcohols ◽  
Evening Primrose Oil ◽  
Evening Primrose ◽  
Murine Peritoneal Macrophages ◽  
Long Chain

α-Tocopherol long-chain metabolite α-13’-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages

2015 ◽  
Vol 59 (8) ◽  
pp. 1524-1534 ◽  
Author(s):  
Maria Wallert ◽  
Lisa Schmölz ◽  
Andreas Koeberle ◽  
Verena Krauth ◽  
Michael Glei ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Raw264.7 Macrophages ◽  
Long Chain

Photochemical Electron Transfer in the System Polypyrrole-Methylene Blue

1994 ◽  
Vol 47 (6) ◽  
pp. 1163 ◽  
Author(s):  
D Matthews ◽  
A Altus ◽  
A Hope
Keyword(s):  
Methylene Blue ◽  
Electron Transfer ◽  
Absorption Spectrum ◽  
Absorption Spectra ◽  
Flash Photolysis ◽  
Laser Flash Photolysis ◽  
Laser Flash ◽  
Vitamin K1 ◽  
Photochemical Reduction ◽  
Long Chain

Methylene Blue incorporated into colloidal oxidized polypyrrole was investigated by absorption spectroscopy and laser flash photolysis. The absorption spectra of Methylene Blue and polypyrrole were unaffected by incorporation. Flash photolysis transients of Methylene Blue and triplet Methylene Blue in ethanol were affected by 1,4-benzoquinone and 1,4-benzoquinol but not by the long-chain naphthoquinone Vitamin K1. Incorporation of Methylene Blue in polypyrrole produced distinct changes in the flash photolysis transients of Methylene Blue and triplet Methylene Blue. Very long-lived transients, with lifetimes of the order of 10 ms, were observed. These effects were accompanied by long-lived changes in the absorption spectrum of Methylene Blue. The transients were modified by the addition of 1,4-benzoquinone but not 1,4-benzoquinol. The results indicate photochemical reduction of oxidized polypyrrole by triplet Methylene Blue with the production of stable long-lived species capable of reducing 1,4-benzoquinone.

scholarly journals Long-chain acyl-CoA synthetase-1 mediates the palmitic acid-induced inflammatory response in human aortic endothelial cells

2020 ◽  
Vol 319 (5) ◽  
pp. E893-E903
Author(s):  
Guang Ren ◽  
Sushant Bhatnagar ◽  
Daniel J. Hahn ◽  
Jeong-a Kim
Keyword(s):  
Endothelial Cells ◽  
Endothelial Dysfunction ◽  
Inflammatory Response ◽  
Proinflammatory Response ◽  
Aortic Endothelial Cells ◽  
Tlr Agonists ◽  
Chain Acyl ◽  
Proinflammatory Responses ◽  
Human Aortic Endothelial Cells ◽  
Long Chain

Saturated fatty acid (SFA) induces proinflammatory response through a Toll-like receptor (TLR)-mediated mechanism, which is associated with cardiometabolic diseases such as obesity, insulin resistance, and endothelial dysfunction. Consistent with this notion, TLR2 or TLR4 knockout mice are protected from obesity-induced proinflammatory response and endothelial dysfunction. Although SFA causes endothelial dysfunction through TLR-mediated signaling pathways, the mechanisms underlying SFA-stimulated inflammatory response are not completely understood. To understand the proinflammatory response in vascular endothelial cells in high-lipid conditions, we compared the proinflammatory responses stimulated by palmitic acid (PA) and other canonical TLR agonists [lipopolysaccharide (LPS), Pam3-Cys-Ser-Lys4 (Pam3CSK4), or macrophage-activating lipopeptide-2)] in human aortic endothelial cells. The expression profiles of E-selectin and the signal transduction pathways stimulated by PA were distinct from those stimulated by canonical TLR agonists. Inhibition of long-chain acyl-CoA synthetases (ACSL) by a pharmacological inhibitor or knockdown of ACSL1 blunted the PA-stimulated, but not the LPS- or Pam3CSK4-stimulated proinflammatory responses. Furthermore, triacsin C restored the insulin-stimulated vasodilation, which was impaired by PA. From the results, we concluded that PA stimulates the proinflammatory response in the vascular endothelium through an ACSL1-mediated mechanism, which is distinct from LPS- or Pam3CSK4-stimulated responses. The results suggest that endothelial dysfunction caused by PA may require to undergo intracellular metabolism. This expands the understanding of the mechanisms by which TLRs mediate inflammatory responses in endothelial dysfunction and cardiovascular disease.

scholarly journals Long-Chain Polyunsaturated Fatty Acids Modulate Lung Inflammatory Response Induced by Pseudomonas aeruginosa in Mice

2005 ◽  
Vol 58 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Stéphane Auvin ◽  
François Collet ◽  
Frédéric Gottrand ◽  
Marie-Odile Husson ◽  
Xavier Leroy ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pseudomonas Aeruginosa ◽  
Inflammatory Response ◽  
Polyunsaturated Fatty Acids ◽  
Long Chain

Omega-3 fatty acids modulate neonatal cytokine response to endotoxin

2016 ◽  
Vol 44 (6) ◽  
Author(s):  
Michael M. Espiritu ◽  
Hong Lin ◽  
Elizabeth Foley ◽  
Valerie Tsang ◽  
Eunice Rhee ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Immune Response ◽  
Inflammatory Response ◽  
Cytokine Response ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Susceptibility To Infection ◽  
Long Chain ◽  
Increased Susceptibility

AbstractNeonatal immune response is characterized by an uncompensated pro-inflammatory response that can lead to inflammation-related morbidity and increased susceptibility to infection. We investigated the effects of long-chain

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