Differential expression profiles of long noncoding RNAs in synchronous multiple and solitary primary esophageal squamous cell carcinomas: A microarray analysis

2018 ◽  
Vol 120 (2) ◽  
pp. 2439-2453 ◽  
Author(s):  
Qi‐Wen Li ◽  
Li Ma ◽  
Bo Qiu ◽  
Hong Yang ◽  
Yu‐Jia Zhu ◽  
...  
Keyword(s):  
Differential Expression ◽  
Microarray Analysis ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Noncoding Rnas ◽  
Squamous Cell Carcinomas ◽  
Long Noncoding Rnas ◽  
Esophageal Squamous Cell Carcinomas

scholarly journals Expression Profile of Long Noncoding RNAs in Human Earlobe Keloids: A Microarray Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Liang Guo ◽  
Kai Xu ◽  
Hongbo Yan ◽  
Haifeng Feng ◽  
Linlin Chai ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Expression Profiles ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Differentially Expressed ◽  
Diagnostic Biomarkers ◽  
Pathway Enrichment ◽  
Normal Tissues ◽  
Wide Range ◽  
Skin Scar

Background. Long noncoding RNAs (lncRNAs) play key roles in a wide range of biological processes and their deregulation results in human disease, including keloids. Earlobe keloid is a type of pathological skin scar, and the molecular pathogenesis of this disease remains largely unknown. Methods. In this study, microarray analysis was used to determine the expression profiles of lncRNAs and mRNAs between 3 pairs of earlobe keloid and normal specimens. Gene Ontology (GO) categories and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to identify the main functions of the differentially expressed genes and earlobe keloid-related pathways. Results. A total of 2068 lncRNAs and 1511 mRNAs were differentially expressed between earlobe keloid and normal tissues. Among them, 1290 lncRNAs and 1092 mRNAs were upregulated, and 778 lncRNAs and 419 mRNAs were downregulated. Pathway analysis revealed that 24 pathways were correlated to the upregulated transcripts, while 11 pathways were associated with the downregulated transcripts. Conclusion. We characterized the expression profiles of lncRNA and mRNA in earlobe keloids and suggest that lncRNAs may serve as diagnostic biomarkers for the therapy of earlobe keloid.

Expression profiles of long noncoding RNAs in cutaneous squamous cell carcinoma

Epigenomics ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 501-518 ◽  
Author(s):  
Michael Sand ◽  
Falk G Bechara ◽  
Daniel Sand ◽  
Thilo Gambichler ◽  
Stephan A Hahn ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Noncoding Rnas ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Long Noncoding Rnas

scholarly journals Identification of the specific long-noncoding RNAs involved in night-break mediated flowering retardation in Chenopodium quinoa

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Qi Wu ◽  
Yiming Luo ◽  
Xiaoyong Wu ◽  
Xue Bai ◽  
Xueling Ye ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Functional Characterization ◽  
Chenopodium Quinoa ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Rna Seq ◽  
Short Day ◽  
Homologous Genes ◽  
The Relationship ◽  
Encoding Genes

Abstract Background Night-break (NB) has been proven to repress flowering of short-day plants (SDPs). Long-noncoding RNAs (lncRNAs) play key roles in plant flowering. However, investigation of the relationship between lncRNAs and NB responses is still limited, especially in Chenopodium quinoa, an important short-day coarse cereal. Results In this study, we performed strand-specific RNA-seq of leaf samples collected from quinoa seedlings treated by SD and NB. A total of 4914 high-confidence lncRNAs were identified, out of which 91 lncRNAs showed specific responses to SD and NB. Based on the expression profiles, we identified 17 positive- and 7 negative-flowering lncRNAs. Co-expression network analysis indicated that 1653 mRNAs were the common targets of both types of flowering lncRNAs. By mapping these targets to the known flowering pathways in model plants, we found some pivotal flowering homologs, including 2 florigen encoding genes (FT (FLOWERING LOCUS T) and TSF (TWIN SISTER of FT) homologs), 3 circadian clock related genes (EARLY FLOWERING 3 (ELF3), LATE ELONGATED HYPOCOTYL (LHY) and ELONGATED HYPOCOTYL 5 (HY5) homologs), 2 photoreceptor genes (PHYTOCHROME A (PHYA) and CRYPTOCHROME1 (CRY1) homologs), 1 B-BOX type CONSTANS (CO) homolog and 1 RELATED TO ABI3/VP1 (RAV1) homolog, were specifically affected by NB and competed by the positive and negative-flowering lncRNAs. We speculated that these potential flowering lncRNAs may mediate quinoa NB responses by modifying the expression of the floral homologous genes. Conclusions Together, the findings in this study will deepen our understanding of the roles of lncRNAs in NB responses, and provide valuable information for functional characterization in future.

Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas

PROTEOMICS ◽  
2015 ◽  
Vol 15 (17) ◽  
pp. 3087-3100 ◽  
Author(s):  
Lihong Hao ◽  
Xin Zhou ◽  
Shuqing Liu ◽  
Mingzhong Sun ◽  
Yang Song ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Gapdh Expression ◽  
Esophageal Squamous Cell Carcinomas ◽  
Proliferation And Invasion

Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH

2002 ◽  
Vol 296 (1) ◽  
pp. 152-155 ◽  
Author(s):  
Tomoki Ishizuka ◽  
Chikako Tanabe ◽  
Hiromi Sakamoto ◽  
Kazuhiko Aoyagi ◽  
Masahiko Maekawa ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Squamous Cell ◽  
Array Cgh ◽  
Squamous Cell Carcinomas ◽  
Dna Array ◽  
Esophageal Squamous Cell Carcinomas
Sign in / Sign up

Export Citation Format

Share Document