Catalpol inhibits TGF‐β1‐induced epithelial‐mesenchymal transition in human non–small‐cell lung cancer cells through the inactivation of Smad2/3 and NF‐κB signaling pathways

2018 ◽  
Vol 120 (2) ◽  
pp. 2251-2258 ◽  
Author(s):  
Zuopei Wang ◽  
Yi Lu ◽  
Bo Sheng ◽  
Yi Ding ◽  
Xiaoke Cheng
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Small Cell ◽  
Small Cell Lung ◽  
Mesenchymal Transition ◽  
Tgf Β1

scholarly journals Knockdown of 14-3-3γ Suppresses Epithelial–Mesenchymal Transition and Reduces Metastatic Potential of Human Non-small Cell Lung Cancer Cells

2018 ◽  
Vol 38 (6) ◽  
pp. 3507-3514 ◽  
Author(s):  
PRITSANA RAUNGRUT ◽  
ANUSARA WONGKOTSILA ◽  
NIDANUT CHAMPOOCHANA ◽  
KRIENGSAK LIRDPRAPAMONGKOL ◽  
JISNUSON SVASTI ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Metastatic Potential ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Mesenchymal Transition

scholarly journals CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0198823 ◽  
Author(s):  
Xiangdong Lu ◽  
Juan Gao ◽  
Yao Zhang ◽  
Tao Zhao ◽  
Hongchuan Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Mesenchymal Transition

scholarly journals The Root Bark of Morus alba L. Suppressed the Migration of Human Non-Small-Cell Lung Cancer Cells through Inhibition of Epithelial–Mesenchymal Transition Mediated by STAT3 and Src

2019 ◽  
Vol 20 (9) ◽  
pp. 2244 ◽  
Author(s):  
Tae-Rin Min ◽  
Hyun-Ji Park ◽  
Moon Nyeo Park ◽  
Bonglee Kim ◽  
Shin-Hyung Park
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Root Bark ◽  
Small Cell Lung ◽  
Mesenchymal Transition

The root bark of Morus alba L. (MA) has been traditionally used for the treatment of various lung diseases in Korea. Although recent research has demonstrated its anticancer effects in several cancer cells, it is still unclear whether MA inhibits the migratory ability of lung cancer cells. The present study investigated the effects of MA on the migration of lung cancer cells and explored the underlying mechanism. Results from a transwell assay and wound-healing assay demonstrated that methylene chloride extracts of MA (MEMA) suppressed the migration and invasion of H1299, H460, and A549 human non-small-cell lung cancer (NSCLC) cells in a concentration-dependent manner. Results from Western blot analyses showed that MEMA reduced the phosphorylation of STAT3 and Src. In addition, MEMA downregulated the expression of epithelial–mesenchymal transition (EMT) marker proteins including Slug, Snail, Vimentin, and N-cadherin, while upregulating the expression of Occludin—a tight-junction protein. The regulation of EMT markers and the decrease of migration by MEMA treatment were reversed once phospho-mimetic STAT3 (Y705D) or Src (Y527F) was transfected into H1299 cells. In conclusions, MEMA inhibited the migratory activity of human NSCLC cells through blocking Src/STAT3-mediated EMT.

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