miR‐345‐5p regulates proliferation, cell cycle, and apoptosis of acute myeloid leukemia cells by targeting AKT2

2018 ◽  
Vol 120 (2) ◽  
pp. 1620-1629 ◽  
Author(s):  
Xiaoyang Ying ◽  
Wanggang Zhang ◽  
Meiyun Fang ◽  
Weijun Zhang ◽  
Chenchen Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Acute Myeloid Leukemia Cells ◽  
Acute Myeloid

scholarly journals Cell Growth Inhibition of Saponin XII from Dipsacus japonicus Miq. on Acute Myeloid Leukemia Cells

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3325
Author(s):  
Ba Thi Cham ◽  
Nguyen Thi Thuy Linh ◽  
Do Thi Thao ◽  
Nguyen Thi Hoang Anh ◽  
Nguyen Thanh Tam ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Myeloid Leukemia ◽  
Cell Growth ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
G1 Phase ◽  
Cell Growth Inhibition ◽  
Acute Myeloid Leukemia Cells ◽  
Apoptotic Effects ◽  
Acute Myeloid

In previous studies, we isolated the known compound saponin XII from the roots of Dipsacus japonicus Miq. Here, we show that this compound reduced the number of acute myeloid leukemia OCI-AML3 cells as evaluated by a hemocytometer. Flow cytometry analyses demonstrated that the reported activity was associated with a significant increase of apoptosis and of cells in the G0/G1 phase of the cell cycle, with a decrease of cells in the S and G2/M phases. Thus, the inhibition of cell growth in OCI-AML3 cells was due to antiproliferative and pro-apoptotic effects. Interestingly, the bioactivity of saponin XII exerted its effect at a concentration as low as 1 µg/mL.

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