Novel TGF‐β1 inhibitor antagonizes TGF‐β1‐induced epithelial‐mesenchymal transition in human A549 lung cancer cells

2018 ◽  
Vol 120 (1) ◽  
pp. 977-987 ◽  
Author(s):  
Ji‐Hoon Jeong ◽  
Hae Jin Jang ◽  
Sungmin Kwak ◽  
Gi‐Jun Sung ◽  
Seung‐Ho Park ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
Human A549 ◽  
Tgf Β1 ◽  
A549 Lung

Diallyl disulphide suppresses the cannonical Wnt signaling pathway and reverses the fibronectin-induced epithelial mesenchymal transition of A549 lung cancer cells

2019 ◽  
Vol 10 (1) ◽  
pp. 191-202 ◽  
Author(s):  
Bornita Das ◽  
Dona Sinha
Keyword(s):  
Lung Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Wnt Signaling Pathway ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
A549 Lung

DADS reflected the potential of reversal of FN-induced EMT by inhibition of Wnt signaling in A549 lung cancer cells.

Luteolin attenuates TGF-β1-induced epithelial–mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt–NF-κB–Snail pathway

Life Sciences ◽  
2013 ◽  
Vol 93 (24) ◽  
pp. 924-933 ◽  
Author(s):  
Kun-Chieh Chen ◽  
Chiu-Yuan Chen ◽  
Chih-Ju Lin ◽  
Tsung-Ying Yang ◽  
Tzu-Hsiu Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
Tgf Β1

scholarly journals LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1674
Author(s):  
Hyun Ji Kim ◽  
Mi Kyung Park ◽  
Hyun Jung Byun ◽  
Minkyoung Kim ◽  
Boram Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Differential Expression ◽  
Malate Dehydrogenase ◽  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
Emt Markers ◽  
Tgf Β1

LW1497 suppresses the expression of the hypoxia-inducing factor (HIF)-1α inhibiting malate dehydrogenase. Although hypoxia and HIF-1α are known to be important in cancer, LW1497 has not been therapeutically applied to cancer yet. Thus, we investigated the effect of LW1497 on the epithelial-mesenchymal transition (EMT) of lung cancer cells. A549 and H1299 lung cancer cells were induced to undergo via TGF-β1 treatment, resulting in the downregulation of E-cadherin and upregulation of N-cadherin and Vimentin concurrently with increases in the migration and invasion capacities of the cells. These effects of TGF-β1 were suppressed upon co-treatment of the cells with LW1497. An RNA-seq analysis revealed that LW1497 induced differential expression of genes related to hypoxia, RNA splicing, angiogenesis, cell migration, and metastasis in the A549 lung cancer cell lines. We confirmed the differential expression of Slug, an EMT-related transcription factor. Results from Western blotting and RT-PCR confirmed that LW1497 inhibited the expression of EMT markers and Slug. After orthotopically transplanting A549 cancer cells into mice, LW1497 was administered to examine whether the lung cancer progression was inhibited. We observed that LW1497 reduced the area of cancer. In addition, the results from immunohistochemical analyses showed that LW1497 downregulated EMT markers and Slug. In conclusion, LW1497 suppresses cancer progression through the inhibition of EMT by downregulating Slug.

scholarly journals Neuropilin-2 Is Upregulated in Lung Cancer Cells during TGF-β1–Induced Epithelial–Mesenchymal Transition

2013 ◽  
Vol 73 (23) ◽  
pp. 7111-7121 ◽  
Author(s):  
Patrick Nasarre ◽  
Robert M. Gemmill ◽  
Vincent A. Potiron ◽  
Joëlle Roche ◽  
Xian Lu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
Tgf Β1
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