Gold nanoparticle and polyethylene glycol in neural regeneration in the treatment of neurodegenerative diseases

2018 ◽  
Vol 120 (3) ◽  
pp. 2749-2755 ◽  
Author(s):  
Tayebe Aghaie ◽  
Mir Hadi Jazayeri ◽  
Mostafa Manian ◽  
leila Khani ◽  
Marjan Erfani ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Neurodegenerative Diseases ◽  
Gold Nanoparticle ◽  
Neural Regeneration

scholarly journals Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review

2014 ◽  
Vol 5 (3) ◽  
pp. 277-294 ◽  
Author(s):  
Sandeep K. Vishwakarma ◽  
Avinash Bardia ◽  
Santosh K. Tiwari ◽  
Syed A.B. Paspala ◽  
Aleem A. Khan
Keyword(s):  
Neurodegenerative Diseases ◽  
Neural Regeneration ◽  
Current Concept

A facile method to in situ fabricate three dimensional gold nanoparticle micropatterns in a cell-resistant hydrogel

2016 ◽  
Vol 15 (2) ◽  
pp. 181-186
Author(s):  
Ming-Hao Yao ◽  
Jie Yang ◽  
Dong-Hui Zhao ◽  
Rui-Xue Xia ◽  
Rui-Mei Jin ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Gold Nanoparticle ◽  
Three Dimensional ◽  
Photochemical Synthesis ◽  
A Cell

A facile method for in situ fabrication of three-dimensional gold nanoparticles micropatterns throughout a polyethylene glycol hydrogel substrate has been developed by combining photochemical synthesis of gold nanoparticles with photolithography technology.

scholarly journals Neurogenesis in the adult Drosophila brain

Genetics ◽  
2021 ◽  
Author(s):  
Kassi L Crocker ◽  
Khailee Marischuk ◽  
Stacey A Rimkus ◽  
Hong Zhou ◽  
Jerry C P Yin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neurodegenerative Diseases ◽  
Glial Cells ◽  
Brain Regions ◽  
Adult Brain ◽  
Neural Regeneration ◽  
Proliferating Cells ◽  
Brain Regeneration ◽  
Adult Drosophila

Abstract Neurodegenerative diseases such as Alzheimer’s and Parkinson’s currently affect ∼25 million people worldwide (Erkkinen et al. 2018). The global incidence of traumatic brain injury (TBI) is estimated at ∼70 million/year (Dewan et al. 2018). Both neurodegenerative diseases and TBI remain without effective treatments. We are utilizing adult Drosophila melanogaster to investigate the mechanisms of brain regeneration with the long term goal of identifying targets for neural regenerative therapies. We specifically focused on neurogenesis, i.e. the generation of new cells, as opposed to the regrowth of specific subcellular structures such as axons. Like mammals, Drosophila have few proliferating cells in the adult brain. Nonetheless, within 24 hours of a Penetrating Traumatic Brain Injury (PTBI) to the central brain, there is a significant increase in the number of proliferating cells. We subsequently detect both new glia and new neurons and the formation of new axon tracts that target appropriate brain regions. Glial cells divide rapidly upon injury to give rise to new glial cells. Other cells near the injury site upregulate neural progenitor genes including asense and deadpan and later give rise to the new neurons. Locomotor abnormalities observed after PTBI are reversed within two weeks of injury, supporting the idea that there is functional recovery. Together, these data indicate that adult Drosophila brains are capable of neuronal repair. We anticipate that this paradigm will facilitate the dissection of the mechanisms of neural regeneration and that these processes will be relevant to human brain repair.

scholarly journals Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion

2019 ◽  
Author(s):  
Francesca Posa ◽  
Elisabeth Baha-Schwab ◽  
Qiang Wei ◽  
Adriana Di Benedetto ◽  
Stefanie Neubauer ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Polyethylene Glycol ◽  
Block Copolymer ◽  
Gold Nanoparticle ◽  
Focal Adhesion ◽  
Β1 Integrin ◽  
Nanoparticle Arrays ◽  
Rgd Peptides ◽  
Selective Ligands ◽  
Integrin Ligands

Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle arrays carrying single BMP-2 dimersare prepared by block-copolymer micellar nanolithography and azide-functionalized integrin ligands (RGD peptides or α<sub>5</sub>β<sub>1</sub>integrin peptidomimetics) are immobilized on the surrounding polyethylene glycol alkyne by click chemistry.

Photochemical transformations of thiolated polyethylene glycol coatings on gold nanoparticles

2016 ◽  
Vol 3 (5) ◽  
pp. 1090-1102 ◽  
Author(s):  
Stacey M. Louie ◽  
Justin M. Gorham ◽  
Eric A. McGivney ◽  
Jingyu Liu ◽  
Kelvin B. Gregory ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Gold Nanoparticle ◽  
Uv Irradiation ◽  
Colloidal Stability ◽  
Chain Scission ◽  
Photochemical Reactions ◽  
Surface Coatings ◽  
Photochemical Transformations ◽  
Thiolated Polyethylene Glycol

Photochemical reactions can cause significant transformations of manufactured nanomaterials and their surface coatings in sunlit environments. In this study, loss of thiolated polyethylene glycol from gold nanoparticle surfaces by chain scission was observed under UV irradiation and resulted in diminished colloidal stability.

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations

2020 ◽  
Vol 15 (2) ◽  
pp. 102-110 ◽  
Author(s):  
Tannaz Akbari Kolagar ◽  
Maryam Farzaneh ◽  
Negin Nikkar ◽  
Seyed Esmaeil Khoshnam
Keyword(s):  
Stem Cells ◽  
Neurodegenerative Diseases ◽  
Pluripotent Stem Cells ◽  
Neurodegenerative Disorders ◽  
Disease Modeling ◽  
Human Pluripotent Stem Cells ◽  
Neural Regeneration ◽  
Patient Specific ◽  
Human Escs ◽  
Human Ipscs

Neurodegenerative diseases are progressive and uncontrolled gradual loss of motor neurons function or death of neuron cells in the central nervous system (CNS) and the mechanisms underlying their progressive nature remain elusive. There is urgent need to investigate therapeutic strategies and novel treatments for neural regeneration in disorders like Alzheimer&#039;s disease (AD), Parkinson&#039;s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Currently, the development and identification of pluripotent stem cells enabling the acquisition of a large number of neural cells in order to improve cell recovery after neurodegenerative disorders. Pluripotent stem cells which consist of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are characterized by their ability to indefinitely self-renew and the capacity to differentiate into different types of cells. The first human ESC lines were established from donated human embryos; while, because of a limited supply of donor embryos, human ESCs derivation remains ethically and politically controversial. Hence, hiPSCs-based therapies have been shown as an effective replacement for human ESCs without embryo destruction. Compared to the invasive methods for derivation of human ESCs, human iPSCs has opened possible to reprogram patient-specific cells by defined factors and with minimally invasive procedures. Human pluripotent stem cells are a good source for cell-based research, cell replacement therapies and disease modeling. To date, hundreds of human ESC and human iPSC lines have been generated with the aim of treating various neurodegenerative diseases. In this review, we have highlighted the recent potentials, advances, and limitations of human pluripotent stem cells for the treatment of neurodegenerative disorders.

scholarly journals Biological Potential of Polyethylene Glycol (PEG)-Functionalized Graphene Quantum Dots in In Vitro Neural Stem/Progenitor Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1446
Author(s):  
Yunseong Ji ◽  
Yu-Meng Li ◽  
Jin Gwan Seo ◽  
Taesu Jang ◽  
Jonathan Campbell Knowles ◽  
...  
Keyword(s):  
Stem Cells ◽  
Quantum Dots ◽  
Stem Cell ◽  
Polyethylene Glycol ◽  
Progenitor Cells ◽  
Functional Groups ◽  
Neural Regeneration ◽  
Cell Labeling ◽  
Surface Functional Groups ◽  
Neural Stem Progenitor Cells

Stem cell therapy is one of the novel and prospective fields. The ability of stem cells to differentiate into different lineages makes them attractive candidates for several therapies. It is essential to understand the cell fate, distribution, and function of transplanted cells in the local microenvironment before their applications. Therefore, it is necessary to develop an accurate and reliable labeling method of stem cells for imaging techniques to track their translocation after transplantation. The graphitic quantum dots (GQDs) are selected among various stem cell labeling and tracking strategies which have high photoluminescence ability, photostability, relatively low cytotoxicity, tunable surface functional groups, and delivering capacity. Since GQDs interact easily with the cell and interfere with cell behavior through surface functional groups, an appropriate surface modification needs to be considered to get close to the ideal labeling nanoprobes. In this study, polyethylene glycol (PEG) is used to improve biocompatibility while simultaneously maintaining the photoluminescent potentials of GQDs. The biochemically inert PEG successfully covered the surface of GQDs. The PEG-GQDs composites show adequate bioimaging capabilities when internalized into neural stem/progenitor cells (NSPCs). Furthermore, the bio-inertness of the PEG-GQDs is confirmed. Herein, we introduce the PEG-GQDs as a valuable tool for stem cell labeling and tracking for biomedical therapies in the field of neural regeneration.

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