The role of high‐mobility group protein box 1 in lung cancer

2018 ◽  
Vol 119 (8) ◽  
pp. 6354-6365 ◽  
Author(s):  
Xiao‐Jin Wu ◽  
Yuan‐Yuan Chen ◽  
Chan‐Chan Gong ◽  
Dong‐Sheng Pei
Keyword(s):  
Lung Cancer ◽  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein

A crucial role of a high mobility group protein HMGA2 in cardiogenesis

2008 ◽  
Vol 10 (5) ◽  
pp. 567-574 ◽  
Author(s):  
Koshiro Monzen ◽  
Yuzuru Ito ◽  
Atsuhiko T. Naito ◽  
Hiroki Kasai ◽  
Yukio Hiroi ◽  
...  
Keyword(s):  
Crucial Role ◽  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein

scholarly journals Role of the Acidic Tail of High Mobility Group Protein B1 (HMGB1) in Protein Stability and DNA Bending

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79572 ◽  
Author(s):  
Fabricio S. Belgrano ◽  
Isabel C. de Abreu da Silva ◽  
Francisco M. Bastos de Oliveira ◽  
Marcelo R. Fantappié ◽  
Ronaldo Mohana-Borges
Keyword(s):  
Protein Stability ◽  
Dna Bending ◽  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein

Stimulation of Transcription in Cultured Cells by High Mobility Group Protein 1: Essential Role of the Acidic Carboxyl-Terminal Region

Biochemistry ◽  
1994 ◽  
Vol 33 (49) ◽  
pp. 14690-14695 ◽  
Author(s):  
Shigemi Aizawa ◽  
Hiroaki Nishino ◽  
Kouhei Saito ◽  
Koichi Kimura ◽  
Hitoshi Shirakawa ◽  
...  
Keyword(s):  
Essential Role ◽  
Cultured Cells ◽  
High Mobility ◽  
Terminal Region ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein ◽  
Carboxyl Terminal ◽  
Stimulation Of

scholarly journals Regulation of TATA-Binding Protein Binding by the SAGA Complex and the Nhp6 High-Mobility Group Protein

2003 ◽  
Vol 23 (6) ◽  
pp. 1910-1921 ◽  
Author(s):  
Yaxin Yu ◽  
Peter Eriksson ◽  
Leena T. Bhoite ◽  
David J. Stillman
Keyword(s):  
Transcription Factor ◽  
Synthetic Lethality ◽  
Binding Protein ◽  
High Mobility ◽  
Tata Binding Protein ◽  
High Mobility Group ◽  
Saga Complex ◽  
High Mobility Group Protein ◽  
Group Protein

ABSTRACT Transcriptional activation of the yeast HO gene involves the sequential action of DNA-binding and chromatin-modifying factors. Here we examine the role of the SAGA complex and the Nhp6 architectural transcription factor in HO regulation. Our data suggest that these factors regulate binding of the TATA-binding protein (TBP) to the promoter. A gcn5 mutation, eliminating the histone acetyltransferase present in SAGA, reduces the transcription of HO, but expression is restored in a gcn5 spt3 double mutant. We conclude that the major role of Gcn5 in HO activation is to overcome repression by Spt3. Spt3 is also part of SAGA, and thus two proteins in the same regulatory complex can have opposing roles in transcriptional regulation. Chromatin immunoprecipitation experiments show that TBP binding to HO is very weak in wild-type cells but markedly increased in an spt3 mutant, indicating that Spt3 reduces HO expression by inhibiting TBP binding. In contrast, it has been shown previously that Spt3 stimulates TBP binding to the GAL1 promoter as well as GAL1 expression, and thus, Spt3 regulates these promoters differently. We also find genetic interactions between TBP and either Gcn5 or the high-mobility-group protein Nhp6, including multicopy suppression and synthetic lethality. These results suggest that, while Spt3 acts to inhibit TBP interaction with the HO promoter, Gcn5 and Nhp6 act to promote TBP binding. The result of these interactions is to limit TBP binding and HO expression to a short period within the cell cycle. Furthermore, the synthetic lethality resulting from combining a gcn5 mutation with specific TBP point mutations can be suppressed by the overexpression of transcription factor IIA (TFIIA), suggesting that histone acetylation by Gcn5 can stimulate transcription by promoting the formation of a TBP/TFIIA complex.

238 EXPRESSION AND ROLE OF HIGH MOBILITY GROUP PROTEIN AT-HOOK 1 (HMGA1) IN RENAL CELL CARCINOMA

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Natsuki Takaha ◽  
Ichiro Takeuchi ◽  
Yoshihiro Sowa ◽  
Yasunori Kimura ◽  
Terukazu Nakamura ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein
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