Sertoli cell specific decline in NOR‐1 leads to germ cell apoptosis and reduced fertility

2018 ◽  
Vol 119 (8) ◽  
pp. 6514-6526 ◽  
Author(s):  
Mansi Shukla ◽  
Nirmalya Ganguli ◽  
Souvik Sen Sharma ◽  
Subeer S. Majumdar
Keyword(s):  
Germ Cell ◽  
Sertoli Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

scholarly journals The Fas System, a Regulator of Testicular Germ Cell Apoptosis, Is Differentially Up-Regulated in Sertoli Cell Versus Germ Cell Injury of the Testis*

Endocrinology ◽  
1999 ◽  
Vol 140 (2) ◽  
pp. 852-858 ◽  
Author(s):  
Jeongwu Lee ◽  
John H. Richburg ◽  
Elizabeth B. Shipp ◽  
Marvin L. Meistrich ◽  
Kim Boekelheide
Keyword(s):  
Germ Cell ◽  
Sertoli Cell ◽  
Cell Apoptosis ◽  
Cell Injury ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis ◽  
System A ◽  
Cell Versus

scholarly journals Cellular and molecular responses of adult testis to changes in nutrition: novel insights from the sheep model

Reproduction ◽  
2017 ◽  
Vol 154 (5) ◽  
pp. R133-R141 ◽  
Author(s):  
Yongjuan Guan ◽  
Graeme B Martin
Keyword(s):  
Germ Cell ◽  
Sertoli Cell ◽  
Cell Apoptosis ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Cell Number ◽  
Sheep Model ◽  
Germ Cell Apoptosis ◽  
Testis Regression ◽  
Male Sheep

This review explores the cellular and molecular mechanisms that regulate spermatogenesis in the post-pubertal testis that is regressing in response to mild undernutrition, using the sexually mature male sheep as a model. Testis regression leads to reductions in daily sperm production and in the quality of ejaculated spermatozoa (poorer movement, DNA damage). There is also a reduction in spermatogenic efficiency that appears to be caused, at least partially, by increases in germ cell apoptosis. Sertoli cell number does not change with testis regression, although about 1% of Sertoli cells do appear to retain proliferative ability after puberty. On the other hand, Sertoli cell function is disrupted during testis regression, as evidenced by a disorganization of tight junctions and indications that cell differentiation and maturation are reversed. Disrupted Sertoli cell function can explain, at least partially, the increase in germ cell apoptosis and any decrease in the rate of spermatogenesis, the two major contributors to spermatogenic efficiency. These outcomes seem to be mediated by changes in two RNA-based processes: (i) the expression of small non-coding RNAs that are involved in the regulation of Sertoli cell function, spermatogenesis and germ cell apoptosis and (ii) alternative pre-mRNA splicing that affects the regulation of spermatogenesis but does not appear to affect germ cell apoptosis, at least during testis progression induced by undernutrition in the male sheep. These research outcomes can be extended to other animal models and are relevant to issues in human male fertility.

Autophagy in Sertoli cell protects against environmental cadmium-induced germ cell apoptosis in mouse testes

2021 ◽  
Vol 270 ◽  
pp. 116241
Author(s):  
Guo-Xiang Zhou ◽  
Hua-Long Zhu ◽  
Xue-Ting Shi ◽  
Yuan Nan ◽  
Wei-Bo Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Sertoli Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

scholarly journals Implications of Sertoli cell induced germ cell apoptosis to testicular pathology

2014 ◽  
Vol 4 (2) ◽  
pp. e979110 ◽  
Author(s):  
Caitlin J Murphy ◽  
John H Richburg
Keyword(s):  
Germ Cell ◽  
Sertoli Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

Bcl-2 and Bax are involved in experimental cryptorchidism-induced testicular germ cell apoptosis in rhesus monkey

Contraception ◽  
2003 ◽  
Vol 68 (4) ◽  
pp. 297-301 ◽  
Author(s):  
Zhi-Hong Zhang ◽  
Xuan Jin ◽  
Xue-Sen Zhang ◽  
Zhao-Yuan Hu ◽  
Ru-Jin Zou ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis
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