Discovery of a novel six‐long non‐coding RNA signature predicting survival of colorectal cancer patients

2018 ◽  
Vol 119 (4) ◽  
pp. 3574-3585 ◽  
Author(s):  
Qiaowei Fan ◽  
Bingrong Liu
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Non Coding Rna ◽  
Colorectal Cancer Patients ◽  
Long Non Coding Rna ◽  
Rna Signature

scholarly journals Long non-coding RNA PVT1 as a novel potential biomarker for predicting the prognosis of colorectal cancer

2018 ◽  
Vol 33 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Heng Fan ◽  
Jian-hua Zhu ◽  
Xue-qing Yao
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Disease Free Survival ◽  
Rank Test ◽  
Free Survival ◽  
Kaplan Meier ◽  
Non Coding Rna ◽  
Potential Biomarker ◽  
Colorectal Cancer Patients ◽  
Long Non Coding Rna

Background: Long non-coding RNA (lncRNA) plays a very important role in the occurrence and development of various tumors, and is a potential biomarker for cancer diagnosis and prognosis. The purpose of this study was to investigate the relationship between the expression of lncRNA plasmacytoma variant translocation 1 (PVT1) and the prognostic significance in patients with colorectal cancer. Methods: The expression of PVT1 was measured by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in cancerous and adjacent tissues of 210 colorectal cancer patients. The disease-free survival and overall survival of colorectal cancer patients were evaluated by Kaplan–Meier analysis, and univariate and multivariate analysis were performed by Cox proportional-hazards model. Results: Our results revealed that PVT1 expression in cancer tissues of colorectal cancer was significantly higher than that of adjacent tissues ( P<0.001). High PVT1 expression was increased by 51.4% (108/210), which was significantly correlated with the tumor differentiation, the depth of invasion, the stage of tumor, node, metastasis (TNM), and lymphatic metastasis. The Kaplan–Meier analysis showed that high PVT1 expression resulted in a shorter disease-free survival (Log-rank test P<0.001) and overall survival (Log-rank test P<0.001) compared with the low PVT1 expression group in colorectal cancer patients, whether at TNM I/II stage or at TNM III/IV stage. A multivariate Cox regression analysis demonstrated that high PVT1 expression was an independent predictor of poor prognosis in colorectal cancer patients. Conclusions: Our results suggest that high PVT1 expression might be a potential biomarker for assessing tumor recurrence and prognosis in colorectal cancer patients.

scholarly journals A long non-coding RNA signature to improve prognosis prediction of colorectal cancer

Oncotarget ◽  
2014 ◽  
Vol 5 (8) ◽  
pp. 2230-2242 ◽  
Author(s):  
Ye Hu ◽  
Hao-Yan Chen ◽  
Chen-Yang Yu ◽  
Jie Xu ◽  
Ji-Lin Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognosis Prediction ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Signature

scholarly journals A long non-coding RNA signature for predicting survival in patients with colorectal cancer

Oncotarget ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 21687-21695 ◽  
Author(s):  
Yi-Lin Wang ◽  
Jun Shao ◽  
Xiaohong Wu ◽  
Tong Li ◽  
Ming Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Signature

Associations of daily partner responses with fatigue interference and relationship satisfaction in colorectal cancer patients.

2018 ◽  
Vol 37 (11) ◽  
pp. 1015-1024
Author(s):  
Fabiola Müller ◽  
Marrit A. Tuinman ◽  
Ellen Stephenson ◽  
Ans Smink ◽  
Anita DeLongis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Relationship Satisfaction ◽  
Cancer Patients ◽  
Colorectal Cancer Patients
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