Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells

2017 ◽  
Vol 119 (4) ◽  
pp. 3317-3325 ◽  
Author(s):  
Zhen‐Qiang Xu ◽  
Ming‐Gen Yang ◽  
Hong‐Jie Liu ◽  
Chen‐Qiang Su
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Circular Rna ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals let-7i inhibits proliferation and migration of bladder cancer cells by targeting HMGA1

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
M-M Qin ◽  
X. Chai ◽  
H-B Huang ◽  
G. Feng ◽  
X-N Li ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2669
Author(s):  
Valentina Pasquale ◽  
Giacomo Ducci ◽  
Gloria Campioni ◽  
Adria Ventrici ◽  
Chiara Assalini ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Lateral Migration ◽  
Metabolic Plasticity ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Sphere Formation ◽  
Proliferation And Migration

Bladder cancer is one of the most prevalent deadly diseases worldwide. Grade 2 tumors represent a good window of therapeutic intervention, whose optimization requires high resolution biomarker identification. Here we characterize energy metabolism and cellular properties associated with spreading and tumor progression of RT112 and 5637, two Grade 2 cancer cell lines derived from human bladder, representative of luminal-like and basal-like tumors, respectively. The two cell lines have similar proliferation rates, but only 5637 cells show efficient lateral migration. In contrast, RT112 cells are more prone to form spheroids. RT112 cells produce more ATP by glycolysis and OXPHOS, present overall higher metabolic plasticity and are less sensitive than 5637 to nutritional perturbation of cell proliferation and migration induced by treatment with 2-deoxyglucose and metformin. On the contrary, spheroid formation is less sensitive to metabolic perturbations in 5637 than RT112 cells. The ability of metformin to reduce, although with different efficiency, cell proliferation, sphere formation and migration in both cell lines, suggests that OXPHOS targeting could be an effective strategy to reduce the invasiveness of Grade 2 bladder cancer cells.

scholarly journals BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1

2018 ◽  
Vol 19 (4) ◽  
pp. 1116 ◽  
Author(s):  
Liyao Gou ◽  
Mengyao Liu ◽  
Jing Xia ◽  
Qun Wan ◽  
Yayun Jiang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2

2018 ◽  
Author(s):  
Haijian Zhang ◽  
Meijuan Jiang ◽  
Qingjun Liu ◽  
Zhixing Han ◽  
Yuqian Zhao ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration
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