Retracted:SHHgene silencing suppresses epithelial-mesenchymal transition, proliferation, invasion, and migration of cervical cancer cells by repressing the hedgehog signaling pathway

2017 ◽  
Vol 119 (5) ◽  
pp. 3829-3842 ◽  
Author(s):  
Feng Zhang ◽  
Chen-Chen Ren ◽  
Ling Liu ◽  
Yan-Nan Chen ◽  
Li Yang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Epithelial Mesenchymal Transition ◽  
Hedgehog Signaling Pathway ◽  
Mesenchymal Transition ◽  
Invasion And Migration ◽  
Cervical Cancer Cells ◽  
And Migration

scholarly journals MicroRNA-200b inhibits epithelial-mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE

2016 ◽  
Vol 13 (4) ◽  
pp. 3139-3146 ◽  
Author(s):  
YAN-XIANG CHENG ◽  
GAN-TAO CHEN ◽  
CHUANG CHEN ◽  
QI-FAN ZHANG ◽  
FENG PAN ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Cervical Cancer Cells ◽  
And Migration

scholarly journals HOTAIR Contributes to Stemness Acquisition of Cervical Cancer through Regulating miR-203 Interaction with ZEB1 on Epithelial-Mesenchymal Transition

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Wenying Zhang ◽  
Jing Liu ◽  
Qiongwei Wu ◽  
Yu Liu ◽  
Chengbin Ma
Keyword(s):  
Cervical Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cultured Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Invasion And Migration ◽  
Cervical Cancer Cells ◽  
And Migration

Cervical cancer stem cells contribute respond to considerable recurrence and metastasis of patients with cervical cancer. The stemness properties were partly regulated by the interaction of lncRNAs and miRNAs. HOTAIR functions as an oncogenic lncRNA. Previous research studies revealed its role in regulating stemness properties in various cancers. However, the role of HOTAIR in cervical cancer stem cells is still unknown. Here, cisplatin-resistant and serum-free cultured cells exhibited stem cells properties. Cervical cancer stem cells exhibited greater invasion and migration compared with their parental cells, which was similar to cells overexpressing HOTAIR. HOTAIR was significantly overexpressed in cervical cancer stem cells, and knockdown of HOTAIR generated statistical downregulation of stemness markers. Additionally, HOTAIR expression was negatively correlated with the level of miR-203, which was found to be an inhibitory miRNA in regulating the expressions of stemness markers. Also, miR-203 expression was negatively correlated with ZEB1. These findings suggested that HOTAIR should be a positive contributor in stemness acquisition of cervical cancer cells, and this effect should correlate with the interaction with miR-203, which can be suppressed by ZEB1.

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