MAPK8 regulates chicken male germ cell differentiation through JNK signaling pathway

2017 ◽  
Vol 119 (2) ◽  
pp. 1548-1557 ◽  
Author(s):  
Yingjie Wang ◽  
Yulin Bi ◽  
Qisheng Zuo ◽  
Wenhui Zhang ◽  
Dong Li ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Germ Cell ◽  
Signaling Pathway ◽  
Male Germ Cell ◽  
Jnk Signaling ◽  
Germ Cell Differentiation ◽  
Jnk Signaling Pathway

scholarly journals YAP creates epiblast responsiveness to inductive signals for germ cell fate

Development ◽  
2021 ◽  
Author(s):  
Saya Kagiwada ◽  
Shinya Aramaki ◽  
Guangming Wu ◽  
Borami Shin ◽  
Eva Kutejova ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Germ Cell ◽  
Signaling Pathway ◽  
Cell Fate ◽  
Cell Lineage ◽  
Signaling Molecules ◽  
Hippo Signaling ◽  
Epiblast Stem Cells ◽  
Germ Cell Differentiation ◽  
Cell Induction

The germ cell lineage in mammals is induced by the stimulation of pluripotent epiblast cells with signaling molecules. Previous studies have suggested that the germ cell differentiation competence or responsiveness of epiblast cells to signaling molecules is established and maintained in epiblast cells of a specific differentiation state. However, the molecular mechanism underlying this process has not been well defined. Here, using the differentiation model of epiblast stem cells (EpiSCs), we have shown that two defined EpiSC lines have robust germ cell differentiation competence. However, another defined EpiSC line has no competence. By evaluating the molecular basis of EpiSCs with distinct germ cell differentiation competence, we identified YAP/YAP1/YAP65, an intracellular mediator of the Hippo signaling pathway, as a critical mediator for establishing germ cell induction. Strikingly, deletion of YAP severely affected responsiveness to inductive stimuli, leading to a defect in WNT target activation and germ cell differentiation. In conclusion, we propose that the Hippo/YAP signaling pathway creates a potential for germ cell fate induction via mesodermal WNT signaling in pluripotent epiblast cells.

Early stages in male germ cell differentiation in the mouse

Apmis ◽  
1998 ◽  
Vol 106 (1-6) ◽  
pp. 127-133 ◽  
Author(s):  
ROBERT ANDERSON ◽  
MARTIN GARCIA-CASTRO ◽  
JANET HEASMAN ◽  
CHRISTOPHER WYLIE
Keyword(s):  
Cell Differentiation ◽  
Germ Cell ◽  
Male Germ Cell ◽  
Early Stages ◽  
Germ Cell Differentiation

Role of Sex Chromosomes in the Control of Male Germ-Cell Differentiation

1991 ◽  
Vol 637 (1 The Male Germ) ◽  
pp. 64-73 ◽  
Author(s):  
MARY HANDEL ◽  
PATRICIA A. HUNT ◽  
MARY C. KOT ◽  
CYNTHIA PARK ◽  
MARK SHANNON
Keyword(s):  
Cell Differentiation ◽  
Germ Cell ◽  
Sex Chromosomes ◽  
Male Germ Cell ◽  
Germ Cell Differentiation

Role of Beta-Catenin in Post-Meiotic Male Germ Cell Differentiation.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 563-563
Author(s):  
Manjeet K. Rao ◽  
Yao-Fu Chang ◽  
Jennifer Lee ◽  
Amiya P. Sinha-Hikim
Keyword(s):  
Cell Differentiation ◽  
Germ Cell ◽  
Male Germ Cell ◽  
Beta Catenin ◽  
Germ Cell Differentiation

scholarly journals Post-meiotic male germ cell differentiation of mouse embryonic stem cells by exposure to conditioned medium

2019 ◽  
Vol 112 (3) ◽  
pp. e101-e102
Author(s):  
Aysha Trout ◽  
Philip Xie ◽  
Alessandra Parrella ◽  
Zev Rosenwaks ◽  
Gianpiero D. Palermo
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Conditioned Medium ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Male Germ Cell ◽  
Germ Cell Differentiation

scholarly journals Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation

2012 ◽  
Vol 109 (15) ◽  
pp. 5750-5755 ◽  
Author(s):  
Y.-F. Chang ◽  
J. S. Lee-Chang ◽  
J. S. Imam ◽  
K. C. Buddavarapu ◽  
S. S. Subaran ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Germ Cell ◽  
Male Germ Cell ◽  
Germ Cell Differentiation ◽  
Translational Suppression

Retinoic acid and 17β‐estradiol improve male germ cell differentiation from mouse‐induced pluripotent stem cells

Andrologia ◽  
2019 ◽  
Vol 52 (2) ◽  
Author(s):  
Javad Amini Mahabadi ◽  
Mohammad Karimian ◽  
Fatemeh Aghighi ◽  
Seyed Ehsan Enderami ◽  
Elahe Seyyed Hosseini ◽  
...  
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Cell Differentiation ◽  
Germ Cell ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Male Germ Cell ◽  
Germ Cell Differentiation ◽  
17Β Estradiol ◽  
Induced Pluripotent

Molecular events and signalling pathways of male germ cell differentiation in mouse

2015 ◽  
Vol 45 ◽  
pp. 84-93 ◽  
Author(s):  
Moïra Rossitto ◽  
Pascal Philibert ◽  
Francis Poulat ◽  
Brigitte Boizet-Bonhoure
Keyword(s):  
Cell Differentiation ◽  
Germ Cell ◽  
Male Germ Cell ◽  
Signalling Pathways ◽  
Germ Cell Differentiation ◽  
Molecular Events
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