Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer

2017 ◽  
Vol 119 (2) ◽  
pp. 1420-1428 ◽  
Author(s):  
Jian Y. Zou ◽  
Chun H. Su ◽  
Hong H. Luo ◽  
Yi Y. Lei ◽  
Bo Zeng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
Regulatory T Cells ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 1 Cells

Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells

2011 ◽  
Vol 141 (3) ◽  
pp. 1014-1023 ◽  
Author(s):  
Tomohisa Sujino ◽  
Takanori Kanai ◽  
Yuichi Ono ◽  
Yohei Mikami ◽  
Atsushi Hayashi ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 1 Cells

scholarly journals Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells

2007 ◽  
Vol 104 (46) ◽  
pp. 18169-18174 ◽  
Author(s):  
J. Wei ◽  
O. Duramad ◽  
O. A. Perng ◽  
S. L. Reiner ◽  
Y.-J. Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Helper ◽  
T Helper 1 ◽  
Developmental Programs

scholarly journals FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1

2010 ◽  
Vol 82 (4) ◽  
pp. 698-705 ◽  
Author(s):  
Jenny Mjösberg ◽  
Göran Berg ◽  
Maria C. Jenmalm ◽  
Jan Ernerudh
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Early Pregnancy ◽  
T Helper ◽  
T Helper 1 ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
T Helper 2

scholarly journals An immune-modulating diet increases the regulatory T cells and reduces T helper 1 inflammatory response in Leishmaniosis affected dogs treated with standard therapy

2015 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura Cortese ◽  
Mariangela Annunziatella ◽  
Anna Teresa Palatucci ◽  
Sarah Lanzilli ◽  
Valentina Rubino ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Response ◽  
Standard Therapy ◽  
T Helper ◽  
T Helper 1

Effect of Interleukin-36β on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis

2020 ◽  
Vol 222 (9) ◽  
pp. 1517-1530
Author(s):  
Yun Ge ◽  
Man Huang ◽  
Ning Dong ◽  
Yong-ming Yao
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cecal Ligation ◽  
Underlying Mechanism ◽  
Effector T Cells ◽  
Autophagic Flux ◽  
T Helper ◽  
T Helper 1 ◽  
Autophagosome Formation ◽  
Autophagic Process

Abstract Background CD4+CD25+ regulatory T cells (Tregs) play an essential role in sepsis-induced immunosuppression. How, the effects of interleukin 36 (IL-36) cytokines on CD4+CD25+ Tregs and their underlying mechanism(s) in sepsis remain unknown. Methods Our study was designed to investigate the impacts of IL-36 cytokines on murine CD4+CD25+ Tregs in presence of lipopolysaccharide (LPS) and in a mouse model of sepsis induced by cecal ligation and puncture (CLP). IL-36–activated autophagy was evaluated by autophagy markers, autophagosome formation, and autophagic flux. Results IL-36α, IL-36β, and IL-36γ were expressed in murine CD4+CD25+ Tregs. Stimulation of CD4+CD25+ Tregs with LPS markedly up-regulated the expression of these cytokines, particularly IL-36β. IL-36β strongly suppressed CD4+CD25+ Tregs under LPS stimulation and in septic mice challenged with CLP, resulting in the amplification of T-helper 1 response and the proliferation of effector T cells. Mechanistic studies revealed that IL-36β triggered autophagy of CD4+CD25+ Tregs. These effects were significantly attenuated in the presence of the autophagy inhibitor 3-methyladenine or Beclin1 knockdown. In addition, early IL-36β administration reduced the mortality rate in mice subjected to CLP. Depletion of CD4+CD25+ Tregs before the onset of sepsis obviously abrogated IL-36β–mediated protection against sepsis. Conclusions These findings suggest that IL-36β diminishes the immunosuppressive activity of CD4+CD25+ Tregs by activating the autophagic process, thereby contributing to improvement of the host immune response and prognosis in sepsis.

scholarly journals Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Erin A. Marshall ◽  
Kevin W. Ng ◽  
Sonia H. Y. Kung ◽  
Emma M. Conway ◽  
Victor D. Martinez ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
Regulatory T Cells ◽  
Cancer Progression ◽  
T Helper ◽  
T Helper 17
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