Mining the Proteome ofLeishmania donovanifor the Development of Novel MHC Class I Restricted Epitope for the Control of Visceral Leishmaniasis

2017 ◽  
Vol 119 (1) ◽  
pp. 378-391 ◽  
Author(s):  
Manas R. Dikhit ◽  
Akhilesh Kumar ◽  
Ajay Amit ◽  
Budheswar Dehury ◽  
Yangya Prasad Nathsharma ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Mhc Class I ◽  
Class I ◽  
Restricted Epitope

CpG oligodeoxynucleotides activate dendritic cells in vivo and induce a functional and protective vaccine immunity against a TERT derived modified cryptic MHC class I-restricted epitope

Vaccine ◽  
2006 ◽  
Vol 24 (11) ◽  
pp. 1880-1888 ◽  
Author(s):  
Sébastien Cornet ◽  
Jeanne Menez-Jamet ◽  
François Lemonnier ◽  
Kostas Kosmatopoulos ◽  
Isabelle Miconnet
Keyword(s):  
Dendritic Cells ◽  
Mhc Class I ◽  
Class I ◽  
Cpg Oligodeoxynucleotides ◽  
Restricted Epitope ◽  
Vaccine Immunity

scholarly journals Presentation of a new H-2Dk-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin

2002 ◽  
Vol 83 (3) ◽  
pp. 641-650 ◽  
Author(s):  
Mehnaaz Lomas ◽  
Emmanuel Hanon ◽  
Yuetsu Tanaka ◽  
Charles R. M. Bangham ◽  
Keith G. Gould
Keyword(s):  
Vaccinia Virus ◽  
Mhc Class I ◽  
Virus Type ◽  
Proteasome Inhibitor ◽  
Class I ◽  
Target Antigen ◽  
Type I ◽  
T Lymphotropic Virus ◽  
Restricted Epitope ◽  
Ctl Responses

Tax, the trans-activator of human T-lymphotropic virus type I (HTLV-I), is the dominant target antigen for cytotoxic T lymphocytes (CTLs) in the majority of infected individuals, although the reason for this immunodominance is not clear. Tax has been shown to associate physically with the proteasome, a protease that is responsible for the generation of the majority of major histocompatibility complex (MHC) class I ligands recognized by CTLs. This association could lead to the preferential targeting of Tax to the MHC class I pathway and account for its high immunogenicity. Here, the CTL response to Tax was investigated in mice by priming with a Tax expression vector and boosting with a Tax recombinant vaccinia virus (modified vaccinia virus Ankara strain). This approach led to the identification of a new H-2Dk-restricted epitope in Tax, amino acid residues 38–46, sequence ARLHRHALL. Surprisingly, presentation of this epitope was found to be enhanced by the proteasome inhibitor lactacystin, although Tax was shown to associate with proteasomes in murine cells. The difficulties encountered in generating Tax-specific CTL responses and the results of enzyme-linked immunospot (ELISpot) analysis suggested that Tax is only poorly immunogenic for CTLs in mice. Therefore, the immunodominance of Tax in human CTL responses to HTLV-I is probably not due to an intrinsic property of the protein itself, such as an association with the proteasome, but instead may result from the fact that Tax is the predominant protein synthesized early after infection.

scholarly journals N-Glycosylation Enhances Presentation of a MHC Class I-Restricted Epitope from Tyrosinase

2009 ◽  
Vol 182 (8) ◽  
pp. 4830-4835 ◽  
Author(s):  
Marina Ostankovitch ◽  
Michelle Altrich-VanLith ◽  
Valentina Robila ◽  
Victor H. Engelhard
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Restricted Epitope
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