High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model

2017 ◽  
Vol 118 (9) ◽  
pp. 2739-2743 ◽  
Author(s):  
Kentaro Igarashi ◽  
Kei Kawaguchi ◽  
Takashi Murakami ◽  
Tasuku Kiyuna ◽  
Kentaro Miyake ◽  
...  
Keyword(s):  
Mouse Model ◽  
Nude Mouse ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Efficacy ◽  
First Line ◽  
Nude Mouse Model ◽  
Cell Sarcoma ◽  
First Line Therapy ◽  
Line Therapy

scholarly journals Ribociclib for the treatment of hormone-positive HER2-negative breast cancer

2019 ◽  
pp. 72-80
Author(s):  
I. P. Ganshina ◽  
D. A. Filonenko ◽  
O. O. Gordeeva ◽  
E. V. Lubennikova ◽  
I. V. Kolyadina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Molecular Diagnostics ◽  
Metastatic Breast ◽  
Topical Issue ◽  
High Efficacy ◽  
First Line ◽  
Mortality Pattern ◽  
First Line Therapy ◽  
Line Therapy

Breast cancer steadily holds leading market positions in the malignancy morbidity and mortality pattern. The treatment of metastatic breast cancer remains an extremely topical issue, when its aim is not only to prolong the patient’s life, but also to preserve its quality. Due to advances in molecular diagnostics, it has become possible to use several new classes of drugs in recent times. CDK4/6 inhibitors that demonstrate high efficacy in the first-line therapy for luminal metastatic breast cancer is one of these groups. This review presents data from recent registration studies and a description of observations from our own clinical experience.

High Efficacy of Paclitaxel and Doxorubicin as First-Line Therapy in Advanced Breast Cancer: A Phase I-II Study

2000 ◽  
Vol 12 (4) ◽  
pp. 367-373 ◽  
Author(s):  
M. De Lena ◽  
A. Latorre ◽  
P. Calabrese ◽  
A. Catino ◽  
V. Lorusso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Phase I ◽  
Advanced Breast Cancer ◽  
Advanced Breast ◽  
High Efficacy ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Ultrastructure of mesotheliomas

1984 ◽  
Vol 42 ◽  
pp. 98-101
Author(s):  
Irving Dardick
Keyword(s):  
Electron Microscopy ◽  
Latent Period ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
Metastatic Adenocarcinoma ◽  
Cell Sarcoma ◽  
Cytological Features ◽  
Industrial Use ◽  
Degree Of Differentiation

With the extensive industrial use of asbestos in this century and the long latent period (20-50 years) between exposure and tumor presentation, the incidence of malignant mesothelioma is now increasing. Thus, surgical pathologists are more frequently faced with the dilemma of differentiating mesothelioma from metastatic adenocarcinoma and spindle-cell sarcoma involving serosal surfaces. Electron microscopy is amodality useful in clarifying this problem.In utilizing ultrastructural features in the diagnosis of mesothelioma, it is essential to appreciate that the classification of this tumor reflects a variety of morphologic forms of differing biologic behavior (Table 1). Furthermore, with the variable histology and degree of differentiation in mesotheliomas it might be expected that the ultrastructure of such tumors also reflects a range of cytological features. Such is the case.

1904: Outcomes of Large Renal Calculi (>2-Cm) Treated with ESWL as First Line Therapy

2004 ◽  
Vol 171 (4S) ◽  
pp. 503-503
Author(s):  
Richard Vanlangendock ◽  
Ramakrishna Venkatesh ◽  
Jamil Rehman ◽  
Chandra P. Sundaram ◽  
Jaime Landman
Keyword(s):  
Renal Calculi ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Is digoxin still justifiable as single first-line therapy in fetal SVT associated with fetal hydrops?

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
DJ Kersten ◽  
J McDougall ◽  
C Schuller ◽  
JP Pfammatter ◽  
L Raio ◽  
...  
Keyword(s):  
First Line ◽  
Fetal Hydrops ◽  
First Line Therapy ◽  
Line Therapy
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