Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism

2017 ◽  
Vol 118 (9) ◽  
pp. 2654-2663 ◽  
Author(s):  
Asie Sadeghi ◽  
Shadi Sadat Seyyed Ebrahimi ◽  
Abolfazl Golestani ◽  
Reza Meshkani
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Independent Mechanism

Protective effect of myokine IL-15 against H2O2-mediated oxidative stress in skeletal muscle cells

2014 ◽  
Vol 41 (11) ◽  
pp. 7715-7722 ◽  
Author(s):  
Fengna Li ◽  
Yinghui Li ◽  
Yulong Tang ◽  
Binbin Lin ◽  
Xiangfeng Kong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Protective Effect ◽  
Muscle Cells ◽  
Skeletal Muscle Cells

Identification of mono-ubiquitinated LDH-A in skeletal muscle cells exposed to oxidative stress

2005 ◽  
Vol 336 (3) ◽  
pp. 799-806 ◽  
Author(s):  
Yuko Onishi ◽  
Katsuya Hirasaka ◽  
Ibuki Ishihara ◽  
Motoko Oarada ◽  
Jumpei Goto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells

scholarly journals A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells

2004 ◽  
Vol 167 (3) ◽  
pp. 417-423 ◽  
Author(s):  
Grazia Camarda ◽  
Francesca Siepi ◽  
Deborah Pajalunga ◽  
Camilla Bernardini ◽  
Rossella Rossi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Dna Synthesis ◽  
Muscle Cells ◽  
Muscle Differentiation ◽  
Conditional Knockout ◽  
Skeletal Muscle Cells ◽  
Specific Gene ◽  
Pocket Protein ◽  
Independent Mechanism ◽  
Optimal Implementation

In skeletal muscle differentiation, the retinoblastoma protein (pRb) is absolutely necessary to establish definitive mitotic arrest. It is widely assumed that pRb is equally essential to sustain the postmitotic state, but this contention has never been tested. Here, we show that terminal proliferation arrest is maintained in skeletal muscle cells by a pRb-independent mechanism. Acute Rb excision from conditional knockout myotubes caused reexpression of E2F transcriptional activity, cyclin-E and -A kinase activities, PCNA, DNA ligase I, RPA, and MCM2, but did not induce DNA synthesis, showing that pRb is not indispensable to preserve the postmitotic state of these cells. Muscle-specific gene expression was significantly down-regulated, showing that pRb is constantly required for optimal implementation of the muscle differentiation program. Rb-deleted myotubes were efficiently reactivated by forced expression of cyclin D1 and Cdk4, indicating a functionally significant target other than pRb for these molecules. Finally, Rb removal induced no DNA synthesis even in pocket-protein null cells. Thus, the postmitotic state of myotubes is maintained by at least two mechanisms, one of which is pocket-protein independent.

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