scholarly journals Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening

2016 ◽  
Vol 118 (2) ◽  
pp. 361-365 ◽  
Author(s):  
Tasuku Kiyuna ◽  
Takashi Murakami ◽  
Yasunori Tome ◽  
Kentaro Igarashi ◽  
Kei Kawaguchi ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Mouse Model ◽  
Drug Screening ◽  
Fluorescent Protein ◽  
Red Fluorescent Protein ◽  
Non Invasive ◽  
Orthotopic Xenograft

scholarly journals A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma

Theranostics ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 155-166 ◽  
Author(s):  
Alexander L. Lazarides ◽  
Melodi J. Whitley ◽  
David B. Strasfeld ◽  
Diana M. Cardona ◽  
Jorge M. Ferrer ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Mouse Model ◽  
Residual Cancer

scholarly journals Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Talya L. Dayton ◽  
Vasilena Gocheva ◽  
Kathryn M. Miller ◽  
Arjun Bhutkar ◽  
Caroline A. Lewis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Mouse Model ◽  
Tumor Initiation ◽  
Specific Deletion

Olaratumab combined with doxorubicin and ifosfamide overcomes individual doxorubicin and olaratumab resistance of an undifferentiated soft-tissue sarcoma in a PDOX mouse model

2019 ◽  
Vol 451 ◽  
pp. 122-127 ◽  
Author(s):  
Takashi Higuchi ◽  
Kentaro Miyake ◽  
Norihiko Sugisawa ◽  
Hiromichi Oshiro ◽  
Zhiying Zhang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Mouse Model

scholarly journals The metabolomic scent of cancer disease progression in soft tissue sarcoma: A case report

2019 ◽  
Vol 34 (2) ◽  
pp. 205-209 ◽  
Author(s):  
Gianmaria Miolo ◽  
Debora Basile ◽  
Andrea Carretta ◽  
Davide Adriano Santeufemia ◽  
Agostino Steffan ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Disease Progression ◽  
Real Time ◽  
Time Analysis ◽  
Cancer Disease ◽  
Non Invasive ◽  
Real Time Analysis ◽  
Volatile Organic

Background: The purpose of this case report is to describe the potential that metabolomics breath analysis may have in cancer disease monitoring. The advances in mass spectrometry instrumentation allow the accurate real-time analysis of volatile metabolites exhaled in the breath. The application of such non-invasive devices may provide innovative and complementary monitoring of the physio-pathological conditions of cancer patients. Case presentation: A 59-year-old Caucasian woman with spindle cell malignant mesenchymal sarcoma of the presacral region started a first-line therapy with non-pegylated liposomal doxorubicin and ifosfamide associated with pelvic radiant treatment. After two cycles of chemotherapy plus radiotherapy, a significant pulmonary disease progression was reported. Thus, a second-line therapy with trabectedin was administered. However, after only two cycles of treatment a re-staging computed tomography scan reported further cancer disease progression of the target pulmonary lesions as well as occurrence of new satellite bilateral nodules. Real-time analysis of breath exhaled volatile organic compounds, performed by select ion flow tube mass spectrometry (SIFT-MS) during the follow-up of the patient, showed a specific metabolic pattern not observed in the breath of other soft tissue sarcoma patients who achieved clinical benefit from the treatments. Conclusions: This case report revealed the importance of the non-invasive real-time volatile organic compounds breath analysis to distinguish individual specific chemo-resistance phenotypes among soft tissue sarcoma patients. Such observation seems to suggest that breath metabolomics may be particularly useful for monitoring cancer disease progression in soft tissue sarcoma patients where only cost-effective diagnostic tools, such as positron emission tomography and computed tomography, are available.

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