Crataegus azarolusLeaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells

2015 ◽  
Vol 117 (5) ◽  
pp. 1262-1272 ◽  
Author(s):  
Nadia Mustapha ◽  
Aline Pinon ◽  
Youness Limami ◽  
Alain Simon ◽  
Kamel Ghedira ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Cycle Arrest ◽  
Colorectal Cancer Cells ◽  
Hct 116 ◽  
Ht 29

scholarly journals Assessment of the Anti-proliferative Effect and Preliminary Analysis of Cell Cycle Arrest and Pro-apoptotic Effects of Balanites aegyptiaca (L.) Delile on Colorectal Cancer Cells HCT-116 and HT-29

2020 ◽  
pp. 9-21
Author(s):  
Wamtinga Richard Sawadogo ◽  
Yun Luo ◽  
Bethany Elkington ◽  
Tong-Chuan He ◽  
Chong-Zhi Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Ethyl Acetate Fraction ◽  
Proliferative Effect ◽  
Cycle Arrest ◽  
Colorectal Cancer Cells ◽  
Hct 116 ◽  
Ht 29

Balanites aegyptiaca (L.) Delile (Zygophyllaceae), is used in traditional medicine for the treatment of intestinal worms, wounds, and inflammatory diseases. The purpose of this study is to assess the anti-proliferative effect and to analyse the pro-apoptotic and cell cycle arrest activities of                     B. aegyptiaca root bark extract and fractions against colorectal cancer cells HCT-116 and HT-29. The cytotoxicity of the crude extract and fractions were evaluated by MTS assay. The most active fractionwas subjected to crystal violet assay, Hoechst staining, cell cycle arrest, and annexin V/PI assays on cancer cells to highlight its mechanisms of action. The ethyl acetate fraction demonstrated the most cytotoxic effect on HCT-116 and HT-29 with IC50 values ranging between 3 and 4 µg/mL. At 10 µg/mL in the cell cycle arrest assay, the fraction increased G1 phase by 3.83% on HCT-116 and by 8.6% on HT-29 whilst G2/M phase was decreased by 5.63% on HCT-116 and by 6.62% on HT-29. Moreover, apoptotic cells were increased by 11.4% on HCT-116. The results suggest a potential source of anticancer molecules against colorectal cancer for isolation from the ethyl acetate fraction.

A natural flavonoid lawsonaringenin induces cell cycle arrest and apoptosis in HT-29 colorectal cancer cells by targeting multiple signalling pathways

2018 ◽  
Vol 45 (5) ◽  
pp. 1339-1348 ◽  
Author(s):  
Areeba Anwar ◽  
Nizam Uddin ◽  
Bina Shaheen Siddiqui ◽  
Rafat Ali Siddiqui ◽  
Sabira Begum ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Signalling Pathways ◽  
Cycle Arrest ◽  
Colorectal Cancer Cells ◽  
Ht 29

scholarly journals Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells

2019 ◽  
Vol 460 (1-2) ◽  
pp. 123-150 ◽  
Author(s):  
Małgorzata Girek ◽  
Karol Kłosiński ◽  
Bartłomiej Grobelski ◽  
Stefania Pizzimenti ◽  
Marie Angele Cucci ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Cycle Arrest ◽  
Colorectal Cancer Cells ◽  
G1 Cell Cycle Arrest ◽  
Ht 29

scholarly journals MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells

2017 ◽  
Vol 38 (3) ◽  
pp. 1783-1789 ◽  
Author(s):  
Na Lam Hwang ◽  
Yong Jung Kang ◽  
Bokyung Sung ◽  
Seong Yeon Hwang ◽  
Jung Yoon Jang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Ros Generation ◽  
Human Colorectal Cancer ◽  
Cycle Arrest ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells
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