scholarly journals Cellular control of connective tissue matrix tension

2013 ◽  
Vol 114 (8) ◽  
pp. 1714-1719 ◽  
Author(s):  
Helene M. Langevin ◽  
Maiken Nedergaard ◽  
Alan K. Howe
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Matrix ◽  
Cellular Control ◽  
Tissue Matrix

Toward a kinetic theory of connective tissue micromechanics

1993 ◽  
Vol 74 (2) ◽  
pp. 665-681 ◽  
Author(s):  
S. M. Mijailovich ◽  
D. Stamenovic ◽  
J. J. Fredberg
Keyword(s):  
Connective Tissue ◽  
Three Dimensional ◽  
Elastic Fibers ◽  
Tissue Elasticity ◽  
Field Equations ◽  
Fiber Network ◽  
Rate Dependent ◽  
Connective Tissue Matrix ◽  
Tissue Matrix ◽  
And Diffusion

The aim of this study is to develop unifying concepts at the microstructural level to account for macroscopic connective tissue dynamics. We establish the hypothesis that rate-dependent and rate-independent dissipative stresses arise in the interaction among fibers in the connective tissue matrix. A quantitative theoretical analysis is specified in terms of geometry and material properties of connective tissue fibers and surrounding constituents. The analysis leads to the notion of slip and diffusion boundary layers, which become unifying concepts in understanding mechanisms that underlie connective tissue elasticity and energy dissipation during various types of loading. The complex three-dimensional fiber network is simplified to the interaction of two ideally elastic fibers that dissipate energy on slipping interface surfaces. The effects of such interactions are assumed to be expressed in the aggregate matrix. Special solutions of the field equations are obtained analytically, whereas the general solution of the model field equations is obtained numerically. The solutions lead to predictions of tissue behavior that are qualitatively, if not quantitatively, consistent with reports of a variety of dynamic moduli, their dependencies on the rate and amplitude of load application, and some features associated with preconditioning.

The morphology of the connective tissue matrix and lymphatic bed of the external genitalia in primary massive localized lymphedema

2020 ◽  
Vol 82 (5) ◽  
pp. 67
Author(s):  
A.D. Ineshina ◽  
S.V. Savchenko ◽  
N.P. Bgatova ◽  
M.Yu. Soluyanov ◽  
V.V. Nimaev
Keyword(s):  
Connective Tissue ◽  
External Genitalia ◽  
Connective Tissue Matrix ◽  
Tissue Matrix

The Ultrastructure of the Connective Tissue Matrix is Significantly Improved Using Cryo-Fixation At High Pressure

2001 ◽  
Vol 7 (S2) ◽  
pp. 1194-1195
Author(s):  
D. Keene ◽  
S. Tufa
Keyword(s):  
High Pressure ◽  
Connective Tissue ◽  
Open Space ◽  
Freeze Substitution ◽  
Basement Membranes ◽  
Lamina Densa ◽  
Connective Tissue Matrix ◽  
Tissue Matrix ◽  
Processing Steps ◽  
Tissue Ultrastructure

The investigation of connective tissue ultrastructure has historically relied on chemical fixation to stabilize micro architecture. These fixatives are not effective in retaining many matrix molecules, including proteoglycans, and allow precipitation of many other components in subsequent processing steps. The result is a preponderance of open space between matrix components. Cells shrink considerably and a precipitation of molecules in highly concentrated regions leads to artifacts including the lamina lucida and lamina densa of basement membranes. Cryo-fixation at high pressure followed by freeze substitution seeks to immobilize tissue components within vitreous (non-crystalline) ice, which is later substituted with acetone at temperatures below the recrystalization temperature of water. Formation of large ice crystals during any part of the preparation protocol significantly distorts structure and can be recognized in the compound microscope. Recognition of smaller freezing artifacts, including microcrystalline ice, is imperative for interpretation of resulting images.

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