Arrest at the G2/M transition of the cell cycle by protein-tyrosine phosphatase inhibition: Studies on a neuronal and a glial cell line

1995 ◽  
Vol 59 (3) ◽  
pp. 389-401 ◽  
Author(s):  
Robert Faure ◽  
Michel Vincent ◽  
Maurice Dufour ◽  
Alan Shaver ◽  
Barry I. Posner
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Glial Cell ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Phosphatase Inhibition ◽  
Inhibition Studies

scholarly journals Functional Analysis of a Cell Cycle–Associated, Tumor-Suppressive Gene, Protein Tyrosine Phosphatase Receptor Type G, in Nasopharyngeal Carcinoma

2008 ◽  
Vol 68 (19) ◽  
pp. 8137-8145 ◽  
Author(s):  
Arthur Kwok Leung Cheung ◽  
Hong Lok Lung ◽  
Siu Chun Hung ◽  
Evan Wai Lok Law ◽  
Yue Cheng ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Functional Analysis ◽  
Nasopharyngeal Carcinoma ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
A Cell

scholarly journals Loss of Protein-tyrosine Phosphatase α (PTPα) Increases Proliferation and Delays Maturation of Oligodendrocyte Progenitor Cells

2012 ◽  
Vol 287 (15) ◽  
pp. 12529-12540 ◽  
Author(s):  
Pei-Shan Wang ◽  
Jing Wang ◽  
Yi Zheng ◽  
Catherine J. Pallen
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Oligodendrocyte Progenitor Cells ◽  
Cell Cycle Exit ◽  
Oligodendrocyte Progenitor ◽  
Protein Tyrosine ◽  
Neural Stem Progenitor Cells

Tightly controlled termination of proliferation determines when oligodendrocyte progenitor cells (OPCs) can initiate differentiation and mature into myelin-forming cells. Protein-tyrosine phosphatase α (PTPα) promotes OPC differentiation, but its role in proliferation is unknown. Here we report that loss of PTPα enhanced in vitro proliferation and survival and decreased cell cycle exit and growth factor dependence of OPCs but not neural stem/progenitor cells. PTPα−/− mice have more oligodendrocyte lineage cells in embryonic forebrain and delayed OPC maturation. On the molecular level, PTPα-deficient mouse OPCs and rat CG4 cells have decreased Fyn and increased Ras, Cdc42, Rac1, and Rho activities, and reduced expression of the Cdk inhibitor p27Kip1. Moreover, Fyn was required to suppress Ras and Rho and for p27Kip1 accumulation, and Rho inhibition in PTPα-deficient cells restored expression of p27Kip1. We propose that PTPα-Fyn signaling negatively regulates OPC proliferation by down-regulating Ras and Rho, leading to p27Kip1 accumulation and cell cycle exit. Thus, PTPα acts in OPCs to limit self-renewal and facilitate differentiation.

scholarly journals Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signaling by the protein tyrosine phosphatase TCPTP

Cell Cycle ◽  
2008 ◽  
Vol 7 (21) ◽  
pp. 3405-3416 ◽  
Author(s):  
Ben J. Shields ◽  
Naomi W. Court ◽  
Christine Hauser ◽  
Patricia E. Bukczynska ◽  
Tony Tiganis
Keyword(s):  
Cell Cycle ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Stat3 Signaling ◽  
Cycle Dependent
Sign in / Sign up

Export Citation Format

Share Document