Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response

1994 ◽  
Vol 54 (4) ◽  
pp. 453-464 ◽  
Author(s):  
Eva Pocsik ◽  
Rudolf Mihalik ◽  
Francis Ali-Osman ◽  
Bharat B. Aggarwal
Keyword(s):  
Tumor Necrosis Factor ◽  
Cell Surface ◽  
Cellular Response ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Human Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Receptors ◽  
Necrosis Factor

scholarly journals Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors.

1990 ◽  
Vol 172 (5) ◽  
pp. 1517-1520 ◽  
Author(s):  
M R Shalaby ◽  
A Sundan ◽  
H Loetscher ◽  
M Brockhaus ◽  
W Lesslauer ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Membrane Receptors ◽  
Tnf Alpha ◽  
Human Tumor Necrosis Factor ◽  
Cellular Functions ◽  
Tumor Necrosis Factor Receptors ◽  
Necrosis Factor

The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-alpha on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater extent by a combination of both mAbs. These observations indicate that TNF interaction with antigenically different components of membrane receptors (p55 and p75) represents a crucial step in transduction of signals for TNF toxicity against U937 and TNF activation of HEC functions.

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