Taurine release associated to volume regulation in rabbit lymphocytes

1991 ◽  
Vol 45 (2) ◽  
pp. 207-212 ◽  
Author(s):  
J. Jesús García ◽  
R. Sánchez Olea ◽  
H. Pasantes-Morales
Glia ◽  
2003 ◽  
Vol 44 (2) ◽  
pp. 119-128 ◽  
Author(s):  
Velia Cardin ◽  
Ruth Lezama ◽  
M. Eugenia Torres-Márquez ◽  
Herminia Pasantes-Morales

2008 ◽  
Vol 45 ◽  
pp. 147-160 ◽  
Author(s):  
Jörg Schaber ◽  
Edda Klipp

Volume is a highly regulated property of cells, because it critically affects intracellular concentration. In the present chapter, we focus on the short-term volume regulation in yeast as a consequence of a shift in extracellular osmotic conditions. We review a basic thermodynamic framework to model volume and solute flows. In addition, we try to select a model for turgor, which is an important hydrodynamic property, especially in walled cells. Finally, we demonstrate the validity of the presented approach by fitting the dynamic model to a time course of volume change upon osmotic shock in yeast.


2021 ◽  
Vol 9 (5) ◽  
pp. 257-258
Author(s):  
Panagiota Anyfanti ◽  
Erasmia Sampani ◽  
Apostolos Tsapas

2021 ◽  
Vol 9 (5) ◽  
pp. 258
Author(s):  
Jesper Jensen ◽  
Massar Omar ◽  
Jacob Eifer Møller ◽  
Morten Schou

2019 ◽  
Vol 400 (11) ◽  
pp. 1481-1496 ◽  
Author(s):  
Lingye Chen ◽  
Benjamin König ◽  
Tianbao Liu ◽  
Sumaira Pervaiz ◽  
Yasmin S. Razzaque ◽  
...  

Abstract The volume-regulated anion channel (VRAC) is a key player in the volume regulation of vertebrate cells. This ubiquitously expressed channel opens upon osmotic cell swelling and potentially other cues and releases chloride and organic osmolytes, which contributes to regulatory volume decrease (RVD). A plethora of studies have proposed a wide range of physiological roles for VRAC beyond volume regulation including cell proliferation, differentiation and migration, apoptosis, intercellular communication by direct release of signaling molecules and by supporting the exocytosis of insulin. VRAC was additionally implicated in pathological states such as cancer therapy resistance and excitotoxicity under ischemic conditions. Following extensive investigations, 5 years ago leucine-rich repeat-containing family 8 (LRRC8) heteromers containing LRRC8A were identified as the pore-forming components of VRAC. Since then, molecular biological approaches have allowed further insight into the biophysical properties and structure of VRAC. Heterologous expression, siRNA-mediated downregulation and genome editing in cells, as well as the use of animal models have enabled the assessment of the proposed physiological roles, together with the identification of new functions including spermatogenesis and the uptake of antibiotics and platinum-based cancer drugs. This review discusses the recent molecular biological insights into the physiology of VRAC in relation to its previously proposed roles.


Author(s):  
Karina Kristensen ◽  
Michael Berenbrink ◽  
Pia Koldkjær ◽  
Augusto Abe ◽  
Tobias Wang

2000 ◽  
Vol 70 (2) ◽  
pp. 633-638
Author(s):  
Xiwu Sun ◽  
Christopher T Ducko ◽  
Eric M Hoenicke ◽  
Karen Reigle ◽  
Ralph J Damiano

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