Mechanism of induction of class I major histocompatibility antigen expression by murine leukemia virus

1988 ◽  
Vol 36 (3) ◽  
pp. 297-309 ◽  
Author(s):  
Douglas V. Faller ◽  
Lise D. Wilson ◽  
David C. Flyer
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Antigen Expression ◽  
Histocompatibility Antigen ◽  
Class I ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
Murine Leukemia

scholarly journals Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice.

1977 ◽  
Vol 146 (1) ◽  
pp. 271-276 ◽  
Author(s):  
E Stockert ◽  
L J Old
Keyword(s):  
Characteristic Feature ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Antigen Expression ◽  
Comparative Tests ◽  
Radiation Induced ◽  
Low Levels ◽  
Murine Leukemia ◽  
Overt Leukemia

Anomalous appearance of TL (thymus-leukemia) antigens is a characteristic feature of radiation-induced leukemias of C57bl/6 mice. We now report that thymocytes of irradiated C57BL/6 mice express TL antigens long before the development of overt leukemia. Thus, TL is a marker for preleukemic changes occurring during radiation leukemogenesis. Low levels of murine leukemia virus (MuLV)-related antigens are also detected on preleukemic thymocytes. Comparative tests on individual mice show no direct correlation between TL and MuLV antigen expression.

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