Leptin regulates estrogen receptor gene expression in ATDC5 cells through the extracellular signal regulated kinase signaling pathway

2012 ◽  
Vol 113 (4) ◽  
pp. 1323-1332 ◽  
Author(s):  
Shan-Jin Wang ◽  
Xin-Feng Li ◽  
Lei-Sheng Jiang ◽  
Li-Yang Dai
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Signaling Pathway ◽  
Receptor Gene ◽  
Kinase Signaling ◽  
Estrogen Receptor Gene ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Kinase Signaling Pathway ◽  
Receptor Gene Expression

scholarly journals Estrogen receptor agonists induce anti-edema effects by altering α and β estrogen receptor gene expression

2021 ◽  
Vol 81 (3) ◽  
pp. 286-294
Author(s):  
Mohammad Khaksari ◽  
Zahra Hajializadeh ◽  
Saeed Esmaeili Mahani ◽  
Zahra Soltani ◽  
Gholamreza Asadikaram
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Receptor Gene ◽  
Estrogen Receptor Gene ◽  
Receptor Agonists ◽  
Receptor Gene Expression

c-fosand estrogen receptor gene expression pattern in the rat uterine epithelium during the estrous cycle

2003 ◽  
Vol 64 (4) ◽  
pp. 379-388 ◽  
Author(s):  
C. Adriana Mendoza-Rodríguez ◽  
Horacio Merchant-Larios ◽  
Maria L. Segura-Valdez ◽  
Norma Moreno-Mendoza ◽  
María E. Cruz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Estrous Cycle ◽  
Expression Pattern ◽  
Receptor Gene ◽  
Gene Expression Pattern ◽  
Uterine Epithelium ◽  
Estrogen Receptor Gene ◽  
Receptor Gene Expression

Downregulation of Estrogen Receptor Gene Expression by Exogenous 17β-Estradiol in the Mammary Glands of Lactating Mice

2006 ◽  
Vol 231 (3) ◽  
pp. 311-316 ◽  
Author(s):  
Toshinobu Hatsumi ◽  
Yutaka Yamamuro
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Mammary Gland ◽  
Single Injection ◽  
Receptor Gene ◽  
Self Regulation ◽  
Estrogen Receptor Gene ◽  
17Β Estradiol ◽  
Nuclear Estrogen Receptor ◽  
Receptor Gene Expression

The biological actions of estrogen are mostly conveyed through interaction with the nuclear estrogen receptor (ER). Previous evidence indicated that estrogen participates in self-regulation through the modulation of the expression of its own receptors. However, the self-regulation of estrogen against ER in the mammary gland during established lactation has not yet been investigated. The present study evaluated ER gene expression in the lactating gland activated by large doses of 17β-estradiol (E2). Repeated E2 treatments dose-dependently decreased the gene, expression of ER, especially its subtype ER-α mRNA, Which was decreased to 10% of the vehicle-injected control by 1 μg E2 injection, whereas it was decreased by 73% for another subtype, ER-β. A single injection of 5 μg of E2 drastically downregulated both ER genes within 12 hrs of injection, and they did not recover to pretreatment level within 48 hrs. Western blot analysis verified that E2 treatment inhibited the phosphorylation of Stat5, which is a potent transcriptional regulator for ER mRNA. The present findings demonstrate that E2 treatment decreases the gene expression of its own receptor in the mammary gland during galactopoesis and induces an apparent transition of the ER profile in the mammary gland during lactation into postlactation.

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