WAVE2, N-WASP, and mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments

2011 ◽  
Vol 112 (11) ◽  
pp. 3421-3429 ◽  
Author(s):  
Kazuhide Takahashi ◽  
Katsuo Suzuki
Keyword(s):  
Cell Invasion ◽  
Actin Filaments ◽  
Phosphatidylinositol 3 Kinase ◽  
Local Accumulation ◽  
Phosphatidylinositol 3

scholarly journals Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion

2005 ◽  
Vol 176 (1) ◽  
pp. 589-593 ◽  
Author(s):  
Domingo F. Barber ◽  
Almira Bartolomé ◽  
Carmen Hernandez ◽  
Juana M. Flores ◽  
Cristina Fernandez-Arias ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Invasion ◽  
Phosphatidylinositol 3 Kinase ◽  
Systemic Lupus ◽  
Class Ib ◽  
Phosphatidylinositol 3

Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis

1998 ◽  
Vol 111 (2) ◽  
pp. 283-294 ◽  
Author(s):  
K. Zhou ◽  
S. Pandol ◽  
G. Bokoch ◽  
A.E. Traynor-Kaplan
Keyword(s):  
Cell Motility ◽  
Mutant Strain ◽  
Actin Filaments ◽  
Cell Structure ◽  
Structure And Function ◽  
Phosphatidylinositol 3 Kinase ◽  
And Function ◽  
Phosphatidylinositol 3

To understand how phosphatidylinositol 3-kinase (PI3K) modulates cell structure and function, we examined the molecular and cellular defects of a Dictyostelium mutant strain (pik1(Delta)2(Delta)) missing two (DdPIK1 and 2) of three PI3K genes, which are homologues of the mammalian p110 subunit. Levels of [32P]phosphatidylinositol 3, 4 bisphosphate (PI(3,4)P2) and [32P]phosphatidylinositol trisphosphate (PIP3) were reduced in pik1(Delta)2(Delta), which had major defects in morphological and functional correlates of macropinocytosis. This was accompanied by dramatic deficits in a subset of F-actin-enriched structures such as circular ruffles, actin crowns and pseudopodia. Although pik1(Delta)2(Delta) were mobile, they failed to aggregate into streams. Therefore we conclude that PIK1 and 2, possibly through modulation of the levels of PIP3 and PI(3,4)P2, regulate the organization of actin filaments necessary for circular ruffling during macropinocytosis, the extension of pseudopodia and the aggregation of cells into streams, but not the regulation of cell motility.

Phosphatidylinositol 3-Kinase Mediates the Ability of Retinol to Decrease Colorectal Cancer Cell Invasion

2014 ◽  
Vol 66 (8) ◽  
pp. 1352-1361 ◽  
Author(s):  
Jennifer N. Griffin Lengyel ◽  
Eun Young Park ◽  
Anna R. Brunson ◽  
Daniel Pinali ◽  
Michelle A. Lane
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Invasion ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3
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