4S polycyclic aromatic hydrocarbon receptor (glycine N-methyltransferase) and the aryl hydrocarbon receptor nuclear translocator (hypoxia inducible factor-1β) interaction in Chinese hamster ovary and rat hepatoma cells: 4S PAH-R/ARNT hetero-oligomers?

2011 ◽  
Vol 112 (8) ◽  
pp. 2015-2018 ◽  
Author(s):  
Kenneth M. Sterling
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Aryl Hydrocarbon Receptor ◽  
Hypoxia Inducible Factor ◽  
Chinese Hamster ◽  
Aromatic Hydrocarbon Receptor ◽  
Aryl Hydrocarbon ◽  
Polycyclic Aromatic ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

scholarly journals Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Marine Drugs ◽  
2019 ◽  
Vol 18 (1) ◽  
pp. 3
Author(s):  
Manon Le Goff ◽  
Antoine Delbrut ◽  
Marie Quinton ◽  
Rémi Pradelles ◽  
Maelle Bescher ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Phaeodactylum Tricornutum ◽  
Protective Action ◽  
Environmental Pollutant ◽  
Bioactive Molecules ◽  
Aromatic Hydrocarbon Receptor ◽  
Ostreococcus Tauri ◽  
Polycyclic Aromatic ◽  
Potential Use

Marine microalgae are known to be a source of bioactive molecules of interest to human health, such as n-3 polyunsaturated fatty acids (n-3 PUFAs) and carotenoids. The fact that some of these natural compounds are known to exhibit anti-inflammatory, antioxidant, anti-proliferative, and apoptosis-inducing effects, demonstrates their potential use in preventing cancers and cardiovascular diseases (CVDs). Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), is an ubiquitous environmental pollutant known to contribute to the development or aggravation of human diseases, such as cancer, CVDs, and immune dysfunction. Most of these deleterious effects are related to the activation of the polycyclic aromatic hydrocarbon receptor (AhR). In this context, two ethanolic microalgal extracts with concentrations of 0.1 to 5 µg/mL are tested, Ostreoccoccus tauri (OT) and Phaeodactylum tricornutum (PT), in order to evaluate and compare their potential effects towards B[a]P-induced toxicity in endothelial HMEC-1 cells. Our results indicate that the OT extract can influence the toxicity of B[a]P. Indeed, apoptosis and the production of extracellular vesicles were decreased, likely through the reduction of the expression of CYP1A1, a B[a]P bioactivation enzyme. Furthermore, the B[a]P-induced expression of the inflammatory cytokines IL-8 and IL1-β was reduced. The PT extract only inhibited the expression of the B[a]P-induced cytokine IL-8 expression. The OT extract therefore seems to be a good candidate for counteracting the B[a]P toxicity.

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