Basic fibroblast growth factor inhibits mineralization but induces neuronal differentiation by human dental pulp stem cells through a FGFR and PLCγ signaling pathway

2011 ◽  
Vol 112 (7) ◽  
pp. 1807-1816 ◽  
Author(s):  
Thanaphum Osathanon ◽  
Nunthawan Nowwarote ◽  
Prasit Pavasant
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Signaling Pathway ◽  
Neuronal Differentiation ◽  
Basic Fibroblast Growth Factor ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Fibroblast Growth ◽  
Human Dental Pulp

scholarly journals Titanium Nanotube Modified With Silver Cross-Linked Basic Fibroblast Growth Factor Improves Osteoblastic Activities of Dental Pulp Stem Cells and Antibacterial Effect

2021 ◽  
Vol 9 ◽  
Author(s):  
Abdullkhaleg Ali Albashari ◽  
Yan He ◽  
Mohammed A. Albaadani ◽  
Yangfan Xiang ◽  
Jihea Ali ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Osteogenic Differentiation ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Dental Pulp ◽  
Antibacterial Properties ◽  
Dental Pulp Stem Cells ◽  
Fibroblast Growth ◽  
M1 Macrophage

Titanium modifications with different silver loading methods demonstrate excellent antibacterial properties. Yet pure silver nanoparticles with limited bioactive properties may delay regeneration of bone surrounding the dental implant. Therefore, loading silver with bioactive drugs on titanium surfaces seems to be a very promising strategy. Herein, we designed a silver (Ag) step-by-step cross-linking with the basic fibroblast growth factor (bFGF) by polydopamine (PDA) and heparin on titanium nanotube (TNT) as its cargo (TNT/PDA/Ag/bFGF) to improve the implant surface. Our results showed that TNT/PDA/Ag/bFGF significantly enhanced the osteogenic differentiation of dental pulp stem cells (DPSCs). It also showed an excellent effect in bacterial inhibition and a reduction of pro-inflammatory factors through inhibition of M1 macrophage activity. These results showed that bFGF cross-linked silver coating on TNTs presented good osteogenic differentiation and early anti-infiammatory and antibacterial properties. Together, this novel design on titanium provides a promising therapeutic for dental implants.

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