scholarly journals Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism

2010 ◽  
Vol 111 (6) ◽  
pp. 1426-1436 ◽  
Author(s):  
Ning Wang ◽  
Yibin Feng ◽  
Meifen Zhu ◽  
Chi-Man Tsang ◽  
Kwan Man ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Cellular Mechanism ◽  
Autophagic Cell Death ◽  
Mitochondrial Apoptosis ◽  
Liver Cancer Cells

Relevance of mitochondrial dysfunction during Sorafenib-induced cell death in liver cancer cells. Role of oxidative and nitrogen reactive species

2021 ◽  
Vol 165 ◽  
pp. 54
Author(s):  
Patricia de la Cruz-Ojeda ◽  
M. Ángeles Rodríguez-Hernández ◽  
Elena Navarro-Villarán ◽  
Paloma Gallego ◽  
Pavla Staňková ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Reactive Species ◽  
Liver Cancer Cells ◽  
Nitrogen Reactive Species

scholarly journals Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

2015 ◽  
Vol 59 (2) ◽  
pp. 178-189 ◽  
Author(s):  
Raquel Ordoñez ◽  
Anna Fernández ◽  
Néstor Prieto-Domínguez ◽  
Laura Martínez ◽  
Carmen García-Ruiz ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Liver Cancer Cells

Tu1642 Cux1 Confers Resistance to Cell Death in Liver Cancer Cells

2016 ◽  
Vol 150 (4) ◽  
pp. S921
Author(s):  
Pietro DiFazio ◽  
Thomas M. Gress ◽  
Sonja Gehring ◽  
Thaddaeus T. Wissniowski
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells

scholarly journals Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation

2021 ◽  
Vol 8 ◽  
Author(s):  
Hong-Yue Lai ◽  
Hsin-Hwa Tsai ◽  
Chia-Jui Yen ◽  
Liang-Yi Hung ◽  
Ching-Chieh Yang ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Binding Protein ◽  
Cohort Analysis ◽  
Growth Factor Receptor ◽  
Study Cohort ◽  
Primary Resistance ◽  
Liver Cancer Cells ◽  
Egfr Expression

Despite the activation of autophagy may enable residual cancer cells to survive and allow tumor relapse, excessive activation of autophagy may eventually lead to cell death. However, the details of the association of autophagy with primary resistance in hepatocellular carcinoma (HCC) remain less clear. In this study, cohort analysis revealed that HCC patients receiving sorafenib with HBV had higher mortality risk. We found that high epidermal growth factor receptor (EGFR) expression and activity may be linked to HBV-induced sorafenib resistance. We further found that the resistance of EGFR-overexpressed liver cancer cells to sorafenib is associated with low activity of AMP-activated protein kinase (AMPK) and CCAAT/enhancer binding protein delta (CEBPD) as well as insufficient autophagic activation. In response to metformin, the AMPK/cAMP-response element binding protein (CREB) pathway contributes to CEBPD activation, which promotes autophagic cell death. Moreover, treatment with metformin can increase sorafenib sensitivity through AMPK activation in EGFR-overexpressed liver cancer cells. This study suggests that AMPK/CEBPD-activated autophagy could be a potent strategy for improving the efficacy of sorafenib in HCC patients.

scholarly journals Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status

Phytomedicine ◽  
2016 ◽  
Vol 23 (1) ◽  
pp. 42-51 ◽  
Author(s):  
Irem Durmaz ◽  
Ebru Bilget Guven ◽  
Tulin Ersahin ◽  
Mehmet Ozturk ◽  
Ihsan Calis ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
Lanatoside C

Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells

2012 ◽  
Vol 35 (5) ◽  
pp. 887-895 ◽  
Author(s):  
Chien-Hang Ni ◽  
Po-Yuan Chen ◽  
Hsu-Feng Lu ◽  
Jai-Sing Yang ◽  
Hui-Ying Huang ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Atp Synthesis ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells
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