Cyclic strain modulates migration and proliferation of vascular smooth muscle cells via Rho-GDIα, Rac1, and p38 pathway

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Ying-Xin Qi ◽  
Ming-Juan Qu ◽  
Zhi-Qiang Yan ◽  
Dan Zhao ◽  
Xiao-Hua Jiang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Cyclic Strain ◽  
Muscle Cells ◽  
P38 Pathway

Pathological cyclic strain promotes proliferation of vascular smooth muscle cells via the ACTH/ERK/STAT3 pathway

2018 ◽  
Vol 119 (10) ◽  
pp. 8260-8270 ◽  
Author(s):  
Xia Tang ◽  
Yanyan Liu ◽  
Qian Xiao ◽  
Qingping Yao ◽  
Molly Allen ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Cyclic Strain ◽  
Muscle Cells ◽  
Stat3 Pathway

Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells

2003 ◽  
Vol 284 (5) ◽  
pp. H1778-H1784 ◽  
Author(s):  
Kazuhiko Asanuma ◽  
Richard Magid ◽  
Chad Johnson ◽  
Robert M. Nerem ◽  
Zorina S. Galis
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Environmental Changes ◽  
Mechanical Strain ◽  
Cyclic Strain ◽  
Muscle Cells ◽  
Uniaxial Strain ◽  
Mrna Levels

Arteries remodel in response to environmental changes. We investigated whether mechanical strain modulates production of matrix metalloproteinase (MMP)-2 and -9 by cultured vascular smooth muscle cells (SMC). MMP-2 and MMP-9 expression were tested using human saphenous vein SMC cultured on silicone membranes at rest or subjected to physiological levels (5%) of stationary or cyclical (1 Hz) uniaxial strain. Compared with control, stationary strain significantly increased MMP-2 mRNA levels at all time points, whereas cyclic strain decreased it after 48 h. Both secreted and cell-associated pro-MMP-2 levels were increased by stationary strain at all times ( P < 0.01), whereas cyclic strain decreased secreted levels after 48 h ( P < 0.02). MMP-9 mRNA levels and pro-MMP-9 protein were increased after 48 h of stationary stretch ( P< 0.01) compared with both no strain and cyclic strain. Our study indicates that vascular SMC show a selective response to different types of strain. We suggest that local increases in stationary mechanical strain resulting from stenting, hypertension, or atherosclerosis may lead to enhanced matrix degradation by SMC.

scholarly journals Role of Cyclic Strain Frequency in Regulating the Alignment of Vascular Smooth Muscle Cells In Vitro

2008 ◽  
Vol 94 (4) ◽  
pp. 1497-1507 ◽  
Author(s):  
Bo Liu ◽  
Ming-Juan Qu ◽  
Kai-Rong Qin ◽  
He Li ◽  
Zhen-Kun Li ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Cyclic Strain ◽  
Muscle Cells ◽  
Strain Frequency

RACK1 Regulates Src Activity on Apoptosis of Vascular Smooth Muscle Cells Induced by Cyclic Strain

2011 ◽  
Vol 4 (3) ◽  
pp. 358-367 ◽  
Author(s):  
Ying-Xin Qi ◽  
Qing-Ping Yao ◽  
Ping Zhang ◽  
Zhi-Qiang Yan ◽  
Zong-Lai Jiang
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Cyclic Strain ◽  
Muscle Cells
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