Adenosine triggers the nuclear translocation of protein kinase C epsilon in H9c2 cardiomyoblasts with the loss of phosphorylation at Ser729

2009 ◽  
Vol 106 (4) ◽  
pp. 633-642 ◽  
Author(s):  
Tian-Rui Xu ◽  
Guiyuan He ◽  
Martin G. Rumsby
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nuclear Translocation ◽  
Kinase C ◽  
Protein Kinase C Epsilon ◽  
H9c2 Cardiomyoblasts

scholarly journals INHIBITION OF PROTEIN KINASE C EPSILON CAUSES CILIATED BOVINE BRONCHIAL CELL DETACHMENT

2006 ◽  
Vol 32 (8) ◽  
pp. 349-362 ◽  
Author(s):  
Rebecca E. Slager ◽  
Joseph H. Sisson ◽  
Jaqueline A. Pavlik ◽  
Jennifer K. Johnson ◽  
Jeremy R. Nicolarsen ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Detachment ◽  
Kinase C ◽  
Protein Kinase C Epsilon

Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts

2002 ◽  
Vol 85 (4) ◽  
pp. 785-797 ◽  
Author(s):  
Souvenir D. Tachado ◽  
Mark W. Mayhew ◽  
Ginger G. Wescott ◽  
Tonia L. Foreman ◽  
Crystal D. Goodwin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tumor Invasion ◽  
Invasion And Metastasis ◽  
Kinase C ◽  
Protein Kinase C Epsilon

scholarly journals Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones)

2015 ◽  
Vol 90 ◽  
pp. 332-341 ◽  
Author(s):  
Jihyae Ann ◽  
Suyoung Yoon ◽  
Jisoo Baek ◽  
Da Hye Kim ◽  
Nancy E. Lewin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Design And Synthesis ◽  
Kinase C ◽  
Protein Kinase C Epsilon

scholarly journals Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

2019 ◽  
Vol 29 (1) ◽  
pp. 183-191.e7 ◽  
Author(s):  
Amanda E. Brandon ◽  
Bing M. Liao ◽  
Barbara Diakanastasis ◽  
Benjamin L. Parker ◽  
Katy Raddatz ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Glucose Tolerance ◽  
Kinase C ◽  
Protein Kinase C Epsilon

scholarly journals Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice

2018 ◽  
Vol 84 (3) ◽  
pp. 193-201 ◽  
Author(s):  
Angelo Blasio ◽  
Jingyi Wang ◽  
Dan Wang ◽  
Florence P. Varodayan ◽  
Matthew B. Pomrenze ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Ethanol Consumption ◽  
Kinase C ◽  
Protein Kinase C Epsilon

Subnanomolar concentration of VIP induces the nuclear translocation of protein kinase C in neonatal rat cortical astrocytes

1994 ◽  
Vol 39 (4) ◽  
pp. 355-363 ◽  
Author(s):  
Z. Oláh ◽  
Cs. Lehel ◽  
W. B. Anderson ◽  
D. E. Brenneman ◽  
D. v. Agoston
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nuclear Translocation ◽  
Neonatal Rat ◽  
Kinase C ◽  
Cortical Astrocytes

Caerulein-induced NF-κB/Rel activation requires both Ca2+ and protein kinase C as messengers

1999 ◽  
Vol 277 (3) ◽  
pp. G678-G686 ◽  
Author(s):  
Yusuke Tando ◽  
Hana Algül ◽  
Martin Wagner ◽  
Hans Weidenbach ◽  
Guido Adler ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nuclear Translocation ◽  
Inhibitory Effect ◽  
Binding Activity ◽  
Atpase Inhibitor ◽  
Kinase C ◽  
Protein Kinase C Activity ◽  
Intracellular Ca ◽  
Iκbα Degradation

The eukaryotic transcription factor NF-κB/Rel is activated by a large variety of stimuli. We have recently shown that NF-κB/Rel is induced during the course of caerulein pancreatitis. Here, we show that activation of NF-κB/Rel by caerulein, a CCK analog, requires increasing intracellular Ca2+ levels and protein kinase C activation. Caerulein induces a dose-dependent increase of nuclear NF-κB/Rel binding activity in pancreatic lobules, which is paralleled by degradation of IκBα. IκBβ was only slightly affected by caerulein treatment. Consistent with an involvement of Ca2+, the endoplasmic reticulum-resident Ca2+-ATPase inhibitor thapsigargin activated NF-κB/Rel in pancreatic lobules. The intracellular Ca2+ chelator TMB-8 prevented IκBα degradation and subsequent nuclear translocation of NF-κB/Rel induced by caerulein. BAPTA-AM was less effective. Cyclosporin A, a Ca2+/calmodulin-dependent protein phosphatase (PP2B) inhibitor, decreased caerulein-induced NF-κB/Rel activation and IκBα degradation. The inhibitory effect of bisindolylmaleimide suggests that protein kinase C activity is also required for caerulein-induced NF-κB/Rel activation. These data suggest that Ca2+- as well as protein kinase C-dependent mechanisms are required for caerulein-induced NF-κB/Rel activation.

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