scholarly journals Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway

2008 ◽  
Vol 105 (4) ◽  
pp. 980-988 ◽  
Author(s):  
Carly M. Kemmis ◽  
JoEllen Welsh
Keyword(s):  
Vitamin D ◽  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Cell Transformation ◽  
Mammary Epithelial

scholarly journals TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Michael D Oberst ◽  
Stacey J Beberman ◽  
Liu Zhao ◽  
Juan Juan Yin ◽  
Yvona Ward ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Cell Transformation ◽  
Mammary Epithelial ◽  
Erk Signaling

scholarly journals Novel SUMO-Protease SENP7S Regulates β-catenin Signaling and Mammary Epithelial Cell Transformation

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Samaneh Karami ◽  
Feng-Ming Lin ◽  
Santosh Kumar ◽  
Shaymaa Bahnassy ◽  
Hariprasad Thangavel ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Cell Transformation ◽  
Mammary Epithelial ◽  
Sumo Protease

Abstract 1: Role of the splicing factor SF2/ASF in mammary epithelial cell transformation

2010 ◽  
Author(s):  
Olga Anczukow ◽  
Avi Rosenberg ◽  
Senthil K. Muthuswamy ◽  
Adrian R. Krainer
Keyword(s):  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Cell Transformation ◽  
Mammary Epithelial ◽  
Splicing Factor

scholarly journals Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism

2011 ◽  
Vol 10 (1) ◽  
pp. 103 ◽  
Author(s):  
Jason D Prescott ◽  
Joanna M Poczobutt ◽  
John J Tentler ◽  
Darius M Walker ◽  
Arthur Gutierrez-Hartmann
Keyword(s):  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Cell Transformation ◽  
Mammary Epithelial

The effect of calcitriol on endoplasmic reticulum stress response

2015 ◽  
Vol 93 (3) ◽  
pp. 268-271 ◽  
Author(s):  
Ela Haddur ◽  
Ali Burak Ozkaya ◽  
Handan Ak ◽  
Hikmet Hakan Aydin
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Endoplasmic Reticulum ◽  
Epithelial Cell ◽  
Er Stress ◽  
Mammary Epithelial Cell ◽  
Mammary Epithelial ◽  
Epithelial Cell Line ◽  
Mammary Epithelial Cell Line ◽  
Anticancer Properties

Calcitriol, the active form of vitamin D, is known for its anticancer properties including induction of apoptosis, inhibition of angiogenesis, and metastasis. Calcitriol also increases intracellular calcium triggering apoptosis in a calpain-dependent manner. Since the main storage unit for cellular calcium is endoplasmic reticulum (ER) and a decrease in ER calcium levels might induce ER stress associated cell death, we hypothesized that the cellular actions of calcitriol occur via ER stress. We have evaluated induction of ER stress by assessing BIP expression and XBP-1 splicing in breast cancer cell lines (MCF-7 and MDA-MB-231) and mammary epithelial cell line MCF10A. Our results suggest that cytotoxic concentrations of calcitriol induce an ER stress related response indicated as increased BIP levels and XBP-1 splicing not only in breast cancer cells but also in mammary epithelial cell line. However, vehicle treatment also induced a similar response de-emphasizing the importance of such effect. Calcitriol also failed to activate calpains, further weakening the idea of ER stress as the main mechanism for apoptotic effects of calcitriol. Taken together our results suggest an association between ER stress and vitamin D signaling. However present data indicates that ER stress by itself is not sufficient to explain anticancer properties of calcitriol.

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