Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma

2008 ◽  
Vol 104 (5) ◽  
pp. 1625-1635 ◽  
Author(s):  
Yi-Jun Qi ◽  
Qing-Yu He ◽  
Yuan-Fang Ma ◽  
Yao-Wu Du ◽  
Guang-Chao Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Proteomic Identification ◽  
Related Proteins

Tumor progression and chemoradiosensitivity in relation to the expression of apoptosis related proteins in esophageal squamous cell carcinoma

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 4588-4588
Author(s):  
S. Tsujitani ◽  
H. Saito ◽  
S. Tatebe ◽  
M. Ikeguchi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Mutant P53 ◽  
Survivin Mrna ◽  
P53 Expression ◽  
Significant Difference ◽  
Related Proteins

4588 To study apoptosis related protein expression and their impact on patient’s survival time and sensitivity to postoperative chemoradiotherapy (CRT), we examined the expression of RB, mutant p53, MDM2 and Bax proteins using immunohistochemistry in 115 (CRT; 42) surgically resected esophageal squamous cell carcinoma (ESCC). We also investigated the survivin mRNA expression with quantitative analysis by real-time RT-PCR in 57 (CRT; 30) patients with ESCC. CRT contained 40–60 Gy radiation and continuous infusion of 5-FU (300mg/sqm, day1–5qw). Expression of RB, mutant p53, MDM2, Bax proteins and survivin mRNA were detected in 65%, 46%, 33%, 37% and 32% of patients, respectively. Patients with RB(+), MDM2(-), Bax(+) or survivin(-) tumor had significantly better survival rates than those with RB(-), MDM2(+), Bax(-) or survivin(+) tumor, respectively. However, there was no significant difference in survival between patients with and without mutant p53 expression. In patients not treated with CRT, those with RB(+) or survivin(-) tumor survived significantly longer than those with RB(-) or survivin(+) tumor, respectively. In patients treated with CRT, the expression of Bax protein and survivin mRNA was prognostic indicator. The 5-year survival rates of patients with Bax(+) and survivin(-) tumors were 65% and 39%, significantly superior to 21% and 0% of those with Bax(-) and survivin(+) tumors (P<0.05 and P<0.01, respectively). These results indicate that the expression levels of apoptosis related proteins are important for predicting the prognosis of ESCC patients. Furthermore, CRT may be effective in patients with Bax(+) or survivin(-) tumors. Further investigations are required for clarifying the relationship between the efficacy of postoperative CRT and apoptosis promoting status of ESCC. No significant financial relationships to disclose.

Expression of apoptosis related proteins and cell cycle regulators in superficial esophageal squamous cell carcinoma

2000 ◽  
Vol 118 (4) ◽  
pp. A537
Author(s):  
Masataka Matsumoto ◽  
Shoji Natsugoe ◽  
Saburo Nakashima ◽  
Hiroshi Okumura ◽  
Hironori Sakita ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Cycle Regulators ◽  
Related Proteins

Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis

2007 ◽  
Vol 1 (3) ◽  
pp. 312-320 ◽  
Author(s):  
Dong-Ping Liu ◽  
Robert Z. Qi ◽  
Yan Wang ◽  
Ping-Ping Chen ◽  
H. Phillip Koeffler ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Proteomic Analysis ◽  
Related Proteins

Clinical Significance and Prognostic Value of Apoptosis Related Proteins in Superficial Esophageal Squamous Cell Carcinoma

2001 ◽  
Vol 8 (7) ◽  
pp. 598-604 ◽  
Author(s):  
Masataka Matsumoto ◽  
Shoji Natsugoe ◽  
Saburo Nakashima ◽  
Hiroshi Okumura ◽  
Hironori Sakita ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Related Proteins

scholarly journals Expression of Bax and Apoptosis-Related Proteins in Human Esophageal Squamous Cell Carcinoma Including Dysplasia

2001 ◽  
Vol 14 (8) ◽  
pp. 741-747 ◽  
Author(s):  
Atsushi Kurabayashi ◽  
Mutsuo Furihata ◽  
Manabu Matsumoto ◽  
Yuji Ohtsuki ◽  
Shiro Sasaguri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Related Proteins

Expression of cell cycle related proteins cyclin D1, p53 and p21WAF1/Cip1 in esophageal squamous cell carcinoma

2010 ◽  
Vol 32 (5) ◽  
pp. 455-460 ◽  
Author(s):  
De-Chen LIN ◽  
Zhi-Zhou SHI ◽  
Li-Yan XUE ◽  
Wei CHEN ◽  
Xin XU ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Related Proteins
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