A potential mechanism for short time exposure to hypoxia-induced DNA synthesis in primary cultured chicken hepatocytes: Correlation between Ca2+/PKC/MAPKs and PI3K/Akt/mTOR

2008 ◽  
Vol 104 (5) ◽  
pp. 1598-1611 ◽  
Author(s):  
Sang Hun Lee ◽  
Min Young Lee ◽  
Jang Hern Lee ◽  
Ho Jae Han
Keyword(s):  
Dna Synthesis ◽  
Potential Mechanism ◽  
Time Exposure ◽  
Short Time

Alteration of intrapancreatic serotonin, homocysteine, TNF-α, and NGF levels as predisposing factors for diabetes following exposure to 900-MHz waves

2021 ◽  
pp. 074823372110226
Author(s):  
Gholamali Jelodar ◽  
Mansour Azimzadeh ◽  
Fatemeh Radmard ◽  
Narges Darvishhoo
Keyword(s):  
Cell Damage ◽  
Pancreatic Beta Cell ◽  
Predisposing Factors ◽  
Male Rats ◽  
Control Group ◽  
Predisposing Factor ◽  
Time Exposure ◽  
Tnf Α ◽  
Long Time ◽  
Short Time

Exposure to mobile phone radiation causes deleterious health effects on biological systems. The objects of this study were to investigate the effect of 900-MHz radiofrequency waves (RFW) emitted from base transceiver station antenna on intrapancreatic homocysteine (Hcy), tumor necrosis factor-α (TNF-α), and nerve growth factor (NGF) as predisposing factors involved in pancreatic beta cell damage. Thirty male rats (Sprague-Dawley, 200 ± 10 g) were randomly divided into the control (without any exposure) and exposed groups: short time (2 h/day), long time (4 h/day), and exposed to 900-MHz RFW for 30 consecutive days. On the last days of the experiment, animals were killed and pancreas tissue was dissected out for evaluation of serotonin, Hcy, TNF-α, and NGF. There was a significant decrease in the serotonin and NGF levels in the pancreatic tissue of exposed groups compared to the control group ( p < 0.05). Also, the levels of serotonin and NGF in the long-time exposure were significantly lower than the short-time exposure ( p < 0.05). However, levels of Hcy and TNF-α were significantly increased in the pancreas of exposed groups compared to the control groups ( p < 0.05). Exposure to 900-MHz RFW decreased pancreatic NGF and serotonin levels and increased the proinflammatory markers (Hcy and TNF-α), which can be a predisposing factor for type 2 diabetes.

Effect of Short-Time Exposure of Sperm on the Fertilization Parameter

2000 ◽  
Vol 74 (3) ◽  
pp. S204-S205 ◽  
Author(s):  
C.S. Hyun ◽  
S.W. Lee ◽  
S.H. Yoon ◽  
W.Y. Son ◽  
S.P. Park ◽  
...  
Keyword(s):  
Time Exposure ◽  
Short Time

scholarly journals Inter-laboratory study of short time exposure (STE) test for predicting eye irritation potential of chemicals and correspondence to globally harmonized system (GHS) classification

2009 ◽  
Vol 34 (6) ◽  
pp. 611-626 ◽  
Author(s):  
Yutaka Takahashi ◽  
Takumi Hayashi ◽  
Shinichi Watanabe ◽  
Kazuhiko Hayashi ◽  
Mirei Koike ◽  
...  
Keyword(s):  
Laboratory Study ◽  
Eye Irritation ◽  
Time Exposure ◽  
Short Time

524 The changes in the parameters of energetic status of the stellate sturgeon Acipenser stellatus Palls spermatozoa after short-time exposure to lead ions in vitro

2003 ◽  
Vol 144 ◽  
pp. s140-s141
Author(s):  
I. Baranowska-Bosiacka ◽  
A. Rzemieniecki ◽  
M. Rutkowska ◽  
G.J. Dietrich ◽  
A. Ciereszko ◽  
...  
Keyword(s):  
Lead Ions ◽  
Time Exposure ◽  
Stellate Sturgeon ◽  
Acipenser Stellatus ◽  
Short Time

A potential mechanism of DL-beta-hydroxybutyrate-induced malformations in mouse embryos

1987 ◽  
Vol 253 (1) ◽  
pp. E72-E80 ◽  
Author(s):  
E. S. Hunter ◽  
T. W. Sadler ◽  
R. E. Wynn
Keyword(s):  
Dna Synthesis ◽  
Ketone Body ◽  
Synergistic Effects ◽  
Krebs Cycle ◽  
Pentose Phosphate ◽  
Mouse Embryos ◽  
Potential Mechanism ◽  
Whole Embryo Culture ◽  
Biochemical Alterations ◽  
Beta Hydroxybutyrate

DL-beta-Hydroxybutyrate (DL-BOHB) is teratogenic to rodent embryos in culture, but the biochemical mechanism(s) responsible for the induction of malformations has not been elucidated. Thus, to delineate a potential mechanism, the interaction of the ketone body with embryonic glucose metabolism was investigated. Mouse embryos were exposed in whole embryo culture to DL-BOHB or each isomer separately during the period of neurulation. The results demonstrate that DL-BOHB inhibits glucose oxidation by the pentose phosphate pathway (PPP) with no concomitant effect on Krebs cycle or glycolysis. Furthermore, decreased rates of embryonic uridine monophosphate and DNA synthesis were produced by DL-BOHB, whereas orotate synthesis was unaffected, thereby suggesting that the availability of ribose moieties synthesized by the PPP was compromised. This hypothesis was supported by the observation that addition of ribose to DL-BOHB-containing medium reduced the incidence of ketone body-induced neural tube defects and maintained the rates of DNA synthesis at control levels. Furthermore, these biochemical alterations are due to the synergistic effects of the D and L isomers and may be related to changes in redox states.

scholarly journals Short time exposure to ambient ozone and associated cardiovascular effects: A panel study of healthy young adults

2020 ◽  
Vol 137 ◽  
pp. 105579 ◽  
Author(s):  
Jie Song ◽  
Jingfang Zhu ◽  
Ge Tian ◽  
Haibin Li ◽  
Huijun Li ◽  
...  
Keyword(s):  
Young Adults ◽  
Panel Study ◽  
Cardiovascular Effects ◽  
Time Exposure ◽  
Ambient Ozone ◽  
Short Time

Development of the short time exposure (STE) test: An in vitro eye irritation test using SIRC cells

2008 ◽  
Vol 22 (3) ◽  
pp. 760-770 ◽  
Author(s):  
Yutaka Takahashi ◽  
Mirei Koike ◽  
Hiroshi Honda ◽  
Yuichi Ito ◽  
Hitoshi Sakaguchi ◽  
...  
Keyword(s):  
Eye Irritation ◽  
Time Exposure ◽  
Irritation Test ◽  
Short Time

Clastogenic and aneugenic effects of short-time and long-time exposure to nanoparticles in a human population

2018 ◽  
Vol 295 ◽  
pp. S207
Author(s):  
A. Rossnerova ◽  
D. Pelclova ◽  
V. Zdimal ◽  
F. Elzeinova ◽  
K. Vrbova ◽  
...  
Keyword(s):  
Human Population ◽  
Time Exposure ◽  
Long Time ◽  
Short Time ◽  
Aneugenic Effects
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