scholarly journals A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene

2007 ◽  
Vol 102 (4) ◽  
pp. 1043-1050 ◽  
Author(s):  
Tadashi Konoshita ◽  
Sébastien Fuchs ◽  
Yasukazu Makino ◽  
Shigeyuki Wakahara ◽  
Isamu Miyamori
Keyword(s):  
Regulatory Element ◽  
Direct Repeat ◽  
Repeat Motif ◽  
Negative Regulatory Element ◽  
Human Renin ◽  
Renin Gene

scholarly journals A PROXIMAL DIRECT REPEAT MOTIF CHARACTERIZED AS A NEGATIVE REGULATORY ELEMENT IN THE HUMAN RENIN GENE

2011 ◽  
Vol 29 ◽  
pp. e380
Author(s):  
T. Konoshita ◽  
S. Mizuno ◽  
Y. Makino ◽  
S. Wakahara ◽  
K. Arakawa ◽  
...  
Keyword(s):  
Regulatory Element ◽  
Direct Repeat ◽  
Repeat Motif ◽  
Negative Regulatory Element ◽  
Human Renin ◽  
Renin Gene

scholarly journals In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer.

1995 ◽  
Vol 96 (3) ◽  
pp. 1230-1237 ◽  
Author(s):  
T Yamada ◽  
M Horiuchi ◽  
R Morishita ◽  
L Zhang ◽  
R E Pratt ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Regulatory Element ◽  
Direct Gene Transfer ◽  
Negative Regulatory Element ◽  
Renin Gene ◽  
Direct Gene

scholarly journals Transcriptional Regulation of Genes Encoding the Selenium-Free [NiFe]-Hydrogenases in the Archaeon Methanococcus voltae Involves Positive and Negative Control Elements

Genetics ◽  
1999 ◽  
Vol 152 (4) ◽  
pp. 1335-1341
Author(s):  
Izabela Noll ◽  
Steffen Müller ◽  
Albrecht Klein
Keyword(s):  
Intergenic Region ◽  
Genetic Information ◽  
Regulatory Element ◽  
Transcription Unit ◽  
Negative Control ◽  
Negative Regulation ◽  
Negative Regulatory Element ◽  
Methanococcus Voltae ◽  
Genes Encoding ◽  
Made In

Abstract Methanococcus voltae harbors genetic information for two pairs of homologous [NiFe]-hydrogenases. Two of the enzymes contain selenocysteine, while the other two gene groups encode apparent isoenzymes that carry cysteinyl residues in the homologous positions. The genes coding for the selenium-free enzymes, frc and vhc, are expressed only under selenium limitation. They are transcribed out of a common intergenic region. A series of deletions made in the intergenic region localized a common negative regulatory element for the vhc and frc promoters as well as two activator elements that are specific for each of the two transcription units. Repeated sequences, partially overlapping the frc promoter, were also detected. Mutations in these repeated heptanucleotide sequences led to a weak induction of a reporter gene under the control of the frc promoters in the presence of selenium. This result suggests that the heptamer repeats contribute to the negative regulation of the frc transcription unit.

scholarly journals Identification of negative and positive regulatory elements in the human renin gene

1989 ◽  
Vol 264 (13) ◽  
pp. 7357-7362 ◽  
Author(s):  
D W Burt ◽  
N Nakamura ◽  
P Kelley ◽  
V J Dzau
Keyword(s):  
Regulatory Elements ◽  
Human Renin ◽  
Renin Gene

scholarly journals Different secretory pathways of renin from mouse cells transfected with the human renin gene.

1988 ◽  
Vol 263 (7) ◽  
pp. 3137-3141
Author(s):  
R E Pratt ◽  
J A Flynn ◽  
P M Hobart ◽  
M Paul ◽  
V J Dzau
Keyword(s):  
Secretory Pathways ◽  
Human Renin ◽  
Renin Gene ◽  
Mouse Cells

scholarly journals The Human Papillomavirus Type 31 Late 3′ Untranslated Region Contains a Complex Bipartite Negative Regulatory Element

2002 ◽  
Vol 76 (12) ◽  
pp. 5993-6003 ◽  
Author(s):  
Sarah A. Cumming ◽  
Claire E. Repellin ◽  
Maria McPhillips ◽  
Jonathan C. Radford ◽  
J. Barklie Clements ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Papillomavirus ◽  
High Risk ◽  
Epithelial Cells ◽  
Regulatory Element ◽  
Capsid Proteins ◽  
Cellular Proteins ◽  
Late Gene Expression ◽  
Hpv 16 ◽  
Negative Regulatory Element

ABSTRACT The papillomavirus life cycle is tightly linked to epithelial cell differentiation. Production of virus capsid proteins is restricted to the most terminally differentiated keratinocytes in the upper layers of the epithelium. However, mRNAs encoding the capsid proteins can be detected in less-differentiated cells, suggesting that late gene expression is controlled posttranscriptionally. Short sequence elements (less than 80 nucleotides in length) that inhibit gene expression in undifferentiated epithelial cells have been identified in the late 3′ untranslated regions (UTRs) of several papillomaviruses, including the high-risk mucosal type human papillomavirus type 16 (HPV-16). Here we show that closely related high-risk mucosal type HPV-31 also contains elements that can act to repress gene expression in undifferentiated epithelial cells. However, the HPV-31 negative regulatory element is surprisingly complex, comprising a major inhibitory element of approximately 130 nucleotides upstream of the late polyadenylation site and a minor element of approximately 110 nucleotides mapping downstream. The first 60 nucleotides of the major element have 68% identity to the negative regulatory element of HPV-16, and these elements bind the same cellular proteins, CstF-64, U2AF65, and HuR. The minor inhibitory element binds some cellular proteins in common with the major inhibitory element, though it also binds certain proteins that do not bind the upstream element.

scholarly journals Haplotypes of the human renin gene associated with essential hypertension and stroke

2000 ◽  
Vol 15 (1) ◽  
pp. 49-55 ◽  
Author(s):  
PM Frossard ◽  
MJ Malloy ◽  
GG Lestringant ◽  
JP Kane
Keyword(s):  
Essential Hypertension ◽  
Human Renin ◽  
Renin Gene
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