Age-dependent telomere-shortening is repressed by phosphorylated α-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes

2007 ◽  
Vol 102 (3) ◽  
pp. 689-703 ◽  
Author(s):  
Yasufumi Tanaka ◽  
Yusuke Moritoh ◽  
Nobuhiko Miwa
Keyword(s):  
Oxidative Stress ◽  
Human Brain ◽  
Stress Reduction ◽  
Telomere Shortening ◽  
Age Dependent ◽  
Intracellular Oxidative Stress

Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress

Life Sciences ◽  
1998 ◽  
Vol 63 (11) ◽  
pp. 935-948 ◽  
Author(s):  
Kayo Furumoto ◽  
Eiji Inoue ◽  
Norio Nagao ◽  
Eiso Hiyama ◽  
Nobuhiko Miwa
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Telomere Shortening ◽  
Age Dependent

scholarly journals Melatonin Promotes In Vitro Maturation of Vitrified-Warmed Mouse Germinal Vesicle Oocytes, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2324
Author(s):  
Shichao Guo ◽  
Jinyu Yang ◽  
Jianpeng Qin ◽  
Izhar Hyder Qazi ◽  
Bo Pan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
In Vitro Maturation ◽  
Germinal Vesicle ◽  
Melatonin Receptors ◽  
Development Rates ◽  
Nrf2 Signaling Pathway ◽  
Mouse Gv Oocytes ◽  
Intracellular Oxidative Stress

Previously it was reported that melatonin could mitigate oxidative stress caused by oocyte cryopreservation; however, the underlying molecular mechanisms which cause this remain unclear. The objective was to explore whether melatonin could reduce oxidative stress during in vitro maturation of vitrified-warmed mouse germinal vesicle (GV) oocytes through the Nrf2 signaling pathway or its receptors. During in vitro maturation of vitrified-warmed mouse GV oocytes, there were decreases (p < 0.05) in the development rates of metaphase I (MI) oocytes and metaphase II (MII) and spindle morphology grades; increases (p < 0.05) in the reactive oxygen species (ROS) levels; and decreases (p < 0.05) in expressions of Nrf2 signaling pathway-related genes (Nrf2, SOD1) and proteins (Nrf2, HO-1). However, adding 10−7 mol/L melatonin to both the warming solution and maturation solutions improved (p < 0.05) these indicators. When the Nrf2 protein was specifically inhibited by Brusatol, melatonin did not increase development rates, spindle morphology grades, genes, or protein expressions, nor did it reduce vitrification-induced intracellular oxidative stress in GV oocytes during in vitro maturation. In addition, when melatonin receptors were inhibited by luzindole, the ability of melatonin to scavenge intracellular ROS was decreased, and the expressions of genes (Nrf2, SOD1) and proteins (Nrf2, HO-1) were not restored to control levels. Therefore, we concluded that 10−7 mol/L melatonin acted on the Nrf2 signaling pathway through its receptors to regulate the expression of genes (Nrf2, SOD1) and proteins (Nrf2, HO-1), and mitigate intracellular oxidative stress, thereby enhancing in vitro development of vitrified-warmed mouse GV oocytes.

scholarly journals Telomere Shortening and Psychiatric Disorders: A Systematic Review

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1423
Author(s):  
Pedro A. Pousa ◽  
Raquel M. Souza ◽  
Paulo Henrique M. Melo ◽  
Bernardo H. M. Correa ◽  
Tamires S. C. Mendonça ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Psychological Distress ◽  
Mental Disorders ◽  
Psychiatric Disorders ◽  
Telomere Length ◽  
Traumatic Stress ◽  
Molecular Mechanisms ◽  
Cochrane Library ◽  
Telomere Shortening ◽  
Anxiety Depression

Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis that mental disorders might have a deeper impact on our physiology and aging than it was previously thought. A systematic search of the literature using MeSH descriptors of psychological distress (“Traumatic Stress Disorder” or “Anxiety Disorder” or “depression”) and telomere length (“cellular senescence”, “oxidative stress” and “telomere”) was conducted on PubMed, Cochrane Library and ScienceDirect databases. A total of 56 studies (113,699 patients) measured the TL from individuals diagnosed with anxiety, depression and posttraumatic disorders and compared them with those from healthy subjects. Overall, TL negatively associates with distress-related mental disorders. The possible underlying molecular mechanisms that underly psychiatric diseases to telomere shortening include oxidative stress, inflammation and mitochondrial dysfunction linking. It is still unclear whether psychological distress is either a cause or a consequence of telomere shortening.

Highly sensitive real-time detection of intracellular oxidative stress and application in mycotoxin toxicity evaluation based on living single-cell electrochemical sensors

The Analyst ◽  
2021 ◽  
Author(s):  
Lu Gao ◽  
Jiadi Sun ◽  
Liping Wang ◽  
Qigao Fan ◽  
Gaowen Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Electrochemical Sensor ◽  
Single Cell ◽  
Real Time ◽  
Electrochemical Sensors ◽  
Living Cells ◽  
Selective Detection ◽  
Toxicity Evaluation ◽  
Highly Sensitive ◽  
Intracellular Oxidative Stress

Single-cell electrochemical sensor is used in the local selective detection of living cells because of its high spatial–temporal resolution and sensitivity, as well as its ability to obtain comprehensive cellular physiological states and processes.

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