Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58

2007 ◽  
Vol 102 (1) ◽  
pp. 28-40 ◽  
Author(s):  
Volker Viereck ◽  
Heide Siggelkow ◽  
Rajeswararao Pannem ◽  
Thomas Braulke ◽  
Jens-Gerd Scharf ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Insulin Like Growth Factor ◽  
In Vitro Differentiation ◽  
Human Osteosarcoma Cell Line ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell

In vitro differentiation potential of a new human osteosarcoma cell line (HOS 58)

1998 ◽  
Vol 63 (2) ◽  
pp. 81-91 ◽  
Author(s):  
Heide Siggelkow ◽  
Christopher Niedhart ◽  
Wiebke Kurre ◽  
Angela Ihbe ◽  
Andreas Schulz ◽  
...  
Keyword(s):  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
In Vitro Differentiation ◽  
Human Osteosarcoma Cell Line ◽  
Differentiation Potential ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell

scholarly journals Formononetin Induces Apoptosis of Human Osteosarcoma Cell Line U2OS by Regulating the Expression of Bcl-2, Bax and MiR-375 In Vitro and In Vivo

2015 ◽  
Vol 37 (3) ◽  
pp. 933-939 ◽  
Author(s):  
Wei Hu ◽  
ZengMing Xiao
Keyword(s):  
Cell Line ◽  
Cell Apoptosis ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Human Osteosarcoma Cell Line ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell ◽  
U2os Cells

Background/Aims: Phytoestrogens are known to prevent tumor progression by inhibiting proliferation and inducing apoptosis in cancer cells. Formononetin is one of the main components of red clover plants, and is considered as a typical phytoestrogen. This study investigates formononetin induction of apoptosis of human osteosarcoma cell line U2OS by regulating Bcl-2 and Bax expression in vitro and in vivo. Methods: U2OS cells were treated with different concentrations of formononetin and the proliferation of the cells was measured using an MTT assay. Cell apoptosis was examined by flow cytometry. The levels of miR-375, Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR. The antitumor activity of formononetin was also evaluated in vivo in nude mice bearing orthotopic tumor implants. Results: High concentrations of formononetin significantly suppress the proliferation of U2OS cells and induce cell apoptosis. Moreover, compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells, while Bax increases. Conclusion: Formononetin has inhibitory effects on the proliferation of U2SO cells, both in vitro and in vivo. This antitumor effect is directly correlated with formononetin concentration.

In vitro evaluation of glass-glass ceramic thermoseed-induced hyperthermia on human osteosarcoma cell line

2011 ◽  
Vol 100A (1) ◽  
pp. 64-71 ◽  
Author(s):  
María Alcaide ◽  
Cecilia Ramírez-Santillán ◽  
María José Feito ◽  
María de la Concepción Matesanz ◽  
Eduardo Ruiz-Hernández ◽  
...  
Keyword(s):  
Cell Line ◽  
Glass Ceramic ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Human Osteosarcoma Cell Line ◽  
In Vitro Evaluation ◽  
Induced Hyperthermia ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

Nature ◽  
1986 ◽  
Vol 319 (6053) ◽  
pp. 511-514 ◽  
Author(s):  
Carl-Henrik Heldin ◽  
Ann Johnsson ◽  
Suzanne Wennergren ◽  
Christer Wernstedt ◽  
Christer Betsholtz ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Human Osteosarcoma Cell Line ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell

scholarly journals IN VIVO AND IN VITRO ANTITUMOR EFFECT OF NUTRIENT SYNERGY ON HUMAN OSTEOSARCOMA CELL LINE MNNG-HOS

2004 ◽  
Vol 12 (1/2) ◽  
pp. 135-145 ◽  
Author(s):  
M. Waheed Roomi ◽  
Vadim Ivanov ◽  
Tatiana Kalinovsky ◽  
Aleksandra Niedzwiecki ◽  
Matthias Rath
Keyword(s):  
Cell Line ◽  
Antitumor Effect ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Human Osteosarcoma Cell Line ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell
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