Basic fibroblast growth factor (FGF-2): The high molecular weight forms come of age

2007 ◽  
Vol 100 (5) ◽  
pp. 1100-1108 ◽  
Author(s):  
Pey-Jen Yu ◽  
Giovanni Ferrari ◽  
Aubrey C. Galloway ◽  
Paolo Mignatti ◽  
Giuseppe Pintucci
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Molecular Weight ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth

Species-Specific High Molecular Weight Forms of Basic Fibroblast Growth Factor

1990 ◽  
Vol 4 (1) ◽  
pp. 45-52 ◽  
Author(s):  
David R. Brigstock ◽  
Michael Klagsbrun ◽  
Joachim Sasse ◽  
Patricia A. Farber ◽  
Niggi Iberg
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Molecular Weight ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Species Specific

High molecular weight immunoreactive basic fibroblast growth factor-like proteins in rat pituitary and brain

1988 ◽  
Vol 90 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Marco Presta ◽  
Marco Foiani ◽  
Marco Rusnati ◽  
Jacquelyn Joseph-Silverstein ◽  
Jeannette A.M. Maier ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Molecular Weight ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Rat Pituitary

scholarly journals Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells.

1991 ◽  
Vol 2 (9) ◽  
pp. 699-708 ◽  
Author(s):  
N Quarto ◽  
D Talarico ◽  
R Florkiewicz ◽  
D B Rifkin
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Molecular Weight ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
3T3 Cells ◽  
Low Levels ◽  
Nih 3T3 ◽  
Nih 3T3 Cells

The phenotypes of NIH 3T3 cells transfected with basic fibroblast growth factor (bFGF) cDNAs that express only the high molecular weight (HMW) forms of bFGF, the 18-kDa form, or all forms were examined. Cells producing the 18 kDa or all forms of bFGF were transformed at high levels of growth factor expression but were nontransformed at low levels. Cell producing low levels of HMW forms of bFGF were growth impaired when compared with the parental cells. These cells tended to form multinucleated giant cells, did not grow in soft agar, were nontumorigenic, had a normal bFGF receptor number, and had a nontransformed morphology. Cells expressing high levels of HMW bFGFs had a transformed morphology and were tumorigenic. These data suggest a specific functional role for HMWbFGF.

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