Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation

2007 ◽  
Vol 101 (5) ◽  
pp. 1109-1124 ◽  
Author(s):  
Dolores Baksh ◽  
Genevieve M. Boland ◽  
Rocky S. Tuan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Wnt Signaling ◽  
Osteogenic Differentiation ◽  
Signaling Pathways ◽  
Cross Talk ◽  
Human Mesenchymal Stem Cells ◽  
Functional Antagonism

Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells

Bone ◽  
2004 ◽  
Vol 34 (5) ◽  
pp. 818-826 ◽  
Author(s):  
Jan de Boer ◽  
Ramakrishnaiah Siddappa ◽  
Claudia Gaspar ◽  
Aart van Apeldoorn ◽  
Ricardo Fodde ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Wnt Signaling ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cells

scholarly journals Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wnt/β-Catenin Signaling Pathways

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Licheng Ni ◽  
Zhihui Kuang ◽  
Zhe Gong ◽  
Deting Xue ◽  
Qiang Zheng
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Signaling Pathways ◽  
Artemisia Annua ◽  
Human Mesenchymal Stem Cells ◽  
Biological Functions ◽  
Low Toxicity ◽  
Underlying Mechanisms ◽  
Important Drug

Dihydroartemisinin (DHA), which is considered to be one of the active compounds within Artemisia annua, has extensively been used in recent years as the most effective drug against malaria, having many biological functions including anticancer, antifungal, and immunomodulatory activities. However, DHA plays a role in the regulation of the proliferation and human mesenchymal stem cells (hMSCs) osteogenic differentiation that remains unknown. We explored DHA’s effect on hMSCs’ proliferation as well as the osteogenic differentiation, together with its underlying mechanisms of action. We showed that DHA enhanced osteogenic differentiation but had no significant effect on hMSCs’ proliferation. It probably exerted its functions through the signaling pathways of ERK1/2 as well as Wnt/β. Because DHA has low toxicity and costs, it might be regarded as an important drug for fracture treatment and tissue engineering.

scholarly journals Regulation of the Wnt Signaling Pathways during Cell Culture of Human Mesenchymal Stem Cells for Efficient Bone Regeneration

2010 ◽  
Vol 7 (2) ◽  
pp. 37-46 ◽  
Author(s):  
Wataru Katagiri ◽  
Yoichi Yamada ◽  
Sayaka Nakamura ◽  
Kenji Ito ◽  
Kenji Hara ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Culture ◽  
Mesenchymal Stem Cells ◽  
Wnt Signaling ◽  
Bone Regeneration ◽  
Signaling Pathways ◽  
Human Mesenchymal Stem Cells

Wnt7a Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells

2019 ◽  
Author(s):  
Leiluo Yang ◽  
Qing Li ◽  
Junhong Zhang ◽  
Pengcheng Li ◽  
Chaoliang Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cells
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