PLP1 alternative splicing in differentiating oligodendrocytes: Characterization of an exonic splicing enhancer

2006 ◽  
Vol 97 (5) ◽  
pp. 999-1016 ◽  
Author(s):  
Erming Wang ◽  
Zhong Huang ◽  
Grace M. Hobson ◽  
Neviana Dimova ◽  
Karen Sperle ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Exonic Splicing Enhancer ◽  
Splicing Enhancer

scholarly journals An exonic splicing enhancer within a bidirectional coding sequence regulates alternative splicing of an antisense mRNA

RNA Biology ◽  
2010 ◽  
Vol 7 (2) ◽  
pp. 179-190 ◽  
Author(s):  
Valerie K. Salato ◽  
Nathaniel W. Rediske ◽  
Chao Zhang ◽  
Michelle L. Hastings ◽  
Stephen Munroe
Keyword(s):  
Alternative Splicing ◽  
Exonic Splicing Enhancer ◽  
Coding Sequence ◽  
Antisense Mrna ◽  
Splicing Enhancer

scholarly journals An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs

2019 ◽  
Vol 12 (1) ◽  
pp. dmm036616 ◽  
Author(s):  
Chunwei Cao ◽  
Ying Zhang ◽  
Qitao Jia ◽  
Xiao Wang ◽  
Qiantao Zheng ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Congenital Hypothyroidism ◽  
Exonic Splicing Enhancer ◽  
Splicing Enhancer

scholarly journals General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 ◽  
Vol 7 (12b) ◽  
pp. 2598-2608 ◽  
Author(s):  
Q Sun ◽  
A Mayeda ◽  
R K Hampson ◽  
A R Krainer ◽  
F M Rottman
Keyword(s):  
Alternative Splicing ◽  
Splicing Factor ◽  
Exonic Splicing Enhancer ◽  
Splicing Enhancer

scholarly journals Interactions among SR proteins, an exonic splicing enhancer, and a lentivirus Rev protein regulate alternative splicing.

1996 ◽  
Vol 16 (5) ◽  
pp. 2325-2331 ◽  
Author(s):  
R R Gontarek ◽  
D Derse
Keyword(s):  
Alternative Splicing ◽  
Exon Skipping ◽  
Sr Proteins ◽  
Splicing Factors ◽  
Exonic Splicing Enhancer ◽  
Exon Inclusion ◽  
Alternative Mrna Splicing ◽  
Splicing Enhancer

We examine here the roles of cellular splicing factors and virus regulatory proteins in coordinately regulating alternative splicing of the tat/rev mRNA of equine infectious anemia virus (EIAV). This bicistronic mRNA contains four exons; exons 1 and 2 encode Tat, and exons 3 and 4 encode Rev. In the absence of Rev expression, the four-exon mRNA is synthesized exclusively, but when Rev is expressed, exon 3 is skipped to produce an mRNA that contains only exons 1, 2, and 4. We identify a purine-rich exonic splicing enhancer (ESE) in exon 3 that promotes exon inclusion. Similar to other cellular ESEs that have been identified by other laboratories, the EIAV ESE interacted specifically with SR proteins, a group of serine/arginine-rich splicing factors that function in constitutive and alternative mRNA splicing. Substitution of purines with pyrimidines in the ESE resulted in a switch from exon inclusion to exon skipping in vivo and abolished binding of SR proteins in vitro. Exon skipping was also induced by expression of EIAV Rev. We show that Rev binds to exon 3 RNA in vitro, and while the precise determinants have not been mapped, Rev function in vivo and RNA binding in vitro indicate that the RNA element necessary for Rev responsiveness overlaps or is adjacent to the ESE. We suggest that EIAV Rev promotes exon skipping by interfering with SR protein interactions with RNA or with other splicing factors.

scholarly journals Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF

2010 ◽  
Vol 38 (19) ◽  
pp. 6684-6696 ◽  
Author(s):  
Zhiqi Chen ◽  
Xuezhong Ma ◽  
Jianhua Zhang ◽  
Jim Hu ◽  
Reginald M. Gorczynski
Keyword(s):  
Alternative Splicing ◽  
Exonic Splicing Enhancer ◽  
Splicing Enhancer
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