Tumor metastasis in an orthotopic murine model of head and neck cancer: Possible role of TGF-beta 1 secreted by the tumor cells

2006 ◽  
Vol 97 (5) ◽  
pp. 1036-1051 ◽  
Author(s):  
Santanu Dasgupta ◽  
Malaya Bhattacharya-Chatterjee ◽  
Bert W. O'Malley ◽  
Sunil K. Chatterjee
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Tumor Cells ◽  
Neck Cancer ◽  
Murine Model ◽  
Tumor Metastasis ◽  
Tgf Beta

scholarly journals Prognostic Role of Blood NETosis in the Progression of Head and Neck Cancer

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 946 ◽  
Author(s):  
Decker ◽  
Pylaeva ◽  
Brenzel ◽  
Spyra ◽  
Droege ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tumor Metastasis ◽  
Tumor Tissue ◽  
Extracellular Traps ◽  
Patients At Risk ◽  
Stimulating Factor ◽  
Net Release

Neutrophil extracellular traps (NETs) represent web-like structures consisting of externalized DNA decorated with granule proteins that are responsible for trapping and killing bacteria. However, undesirable effects of NET formation during carcinogenesis, such as metastasis support, have been described. In the present study, we evaluated the correlation between NETosis and disease progression in head and neck cancer (HNC) patients in order to establish a valid biomarker for an early detection and monitoring of HNC progression. Moreover, factors influencing NET release in HNC patients were revealed. We showed a significantly elevated vital NETosis in neutrophils isolated from early T1–T2 and N0–N2 stage patients, as compared to healthy controls. Additionally, in our experimental setting, we confirmed the involvement of tumor cells in the stimulation of NET formation. Interestingly, in advanced cancer stages (T3–4, N3) NETosis was reduced. This also correlated with the levels of granulocyte colony-stimulating factor (G-CSF) in plasma and tumor tissue. Altogether, we suggest that the elevated NETosis in blood can be used as a biomarker to detect early HNC and to predict patients at risk to develop tumor metastasis. Therapeutic disruption of NET formation may offer new roads for successful treatment of HNC patients in order to prevent metastasis.

The Role of Neck Dissection after Radical Chemoradiation for Locally Advanced Head and Neck Cancer: Should We Move Back

Oncology ◽  
2013 ◽  
Vol 84 (3) ◽  
pp. 174-185 ◽  
Author(s):  
N. Denaro ◽  
E.G. Russi ◽  
G. Numico ◽  
T. Pazzaia ◽  
R. Vitiello ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head

scholarly journals Role of near-infrared fluorescence imaging in head and neck cancer surgery: from animal models to humans

2014 ◽  
Vol 272 (10) ◽  
pp. 2593-2600 ◽  
Author(s):  
Ihab Atallah ◽  
Clément Milet ◽  
Jean-Luc Coll ◽  
Emile Reyt ◽  
Christian Adrien Righini ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Animal Models ◽  
Head And Neck ◽  
Fluorescence Imaging ◽  
Neck Cancer ◽  
Near Infrared ◽  
Cancer Surgery ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

Management of severe bio-radiation dermatitis induced by radiotherapy and cetuximab in patients with head and neck cancer: emphasizing the role of calcium alginate dressings

2018 ◽  
Vol 27 (8) ◽  
pp. 2957-2967 ◽  
Author(s):  
Pierluigi Bonomo ◽  
Isacco Desideri ◽  
Mauro Loi ◽  
Lucia Pia Ciccone ◽  
Monica Lo Russo ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Calcium Alginate ◽  
Radiation Dermatitis
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