Retinoic acid induced repression of AP-1 activity is mediated by protein phosphatase 2A in ovarian carcinoma cells

2005 ◽  
Vol 96 (1) ◽  
pp. 170-182 ◽  
Author(s):  
Carmilia Jiménez Ramírez ◽  
Juliet M. Haberbusch ◽  
Dianne Robert Soprano ◽  
Kenneth J. Soprano
Keyword(s):  
Retinoic Acid ◽  
Ovarian Carcinoma ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Carcinoma Cells ◽  
Ovarian Carcinoma Cells ◽  
Phosphatase 2A

scholarly journals Protein Phosphatase 2A Associates with Rb2/p130 and Mediates Retinoic Acid-induced Growth Suppression of Ovarian Carcinoma Cells

2003 ◽  
Vol 278 (43) ◽  
pp. 41881-41889 ◽  
Author(s):  
Scott Vuocolo ◽  
Enkhtsetseg Purev ◽  
Dongmei Zhang ◽  
Jiri Bartek ◽  
Klaus Hansen ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Ovarian Carcinoma ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Growth Suppression ◽  
Carcinoma Cells ◽  
Ovarian Carcinoma Cells ◽  
Phosphatase 2A

scholarly journals The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity

2014 ◽  
Vol 14 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Ki-Eun Chang ◽  
Bih-Rong Wei ◽  
James P. Madigan ◽  
Matthew D. Hall ◽  
R. Mark Simpson ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Carcinoma Cells ◽  
Ovarian Carcinoma Cells ◽  
Phosphatase 2A

Interrelationship between protein phosphatase-2A and cytoskeletal architecture during the endothelial cell response to soluble products produced by human head and neck cancer

2000 ◽  
Vol 122 (5) ◽  
pp. 721-727 ◽  
Author(s):  
Christopher J. Witt ◽  
Steven P. Gabel ◽  
Jeremy Meisinger ◽  
Gwendolyn Werra ◽  
Shirley W. Liu ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Retinoic Acid ◽  
Endothelial Cell ◽  
Cell Motility ◽  
Head And Neck ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Human Head ◽  
Progressive Development ◽  
Phosphatase 2A

Tumor neovascularization is necessary for the progressive development of all solid tumors, including head and neck squamous cell carcinomas (HNSCCs). The angiogenic process includes increased endothelial cell motility. Our prior studies have shown the importance of protein phosphatase-2A (PP-2A) in restricting endothelial cell motility. Because motility is regulated by the polymerization/depolymerization of the cellular cytoskeleton, the present study defined the interrelationship between PP-2A and the cytoskeleton during endothelial cell responses to HNSCC-derived angiogenic factors. PP-2A was shown to colocalize with microtubules of unstimulated endothelial cells. However, exposure to HNSCC-derived products resulted in a more diffuse distribution of PP-2A staining and a loss of filamentous tubulin. The feasibility of pharmacologically preventing this cytoskeletal disorganization as a means of blocking tumor-induced angiogenesis was tested. This was accomplished by use of 1α,25-dihydroxyvitamin D3 [1,25 (OH)2D3] and all- trans-retinoic acid to indirectly stimulate PP-2A activity through their capacity to elevated intracellular levels of the second messenger ceramide. Pretreatment of endothelial cells with either 1,25(OH)2D3 or retinoic acid prevented the cytoskeletal disorganization that otherwise occurs in endothelial cells on exposure to HNSCC-derived products. These studies support the feasibility of using elevation of PP-2A to prevent the morphogenic component of the angiogenic process that is stimulated by HNSCC-derived factors.

Retinoic acid induced death of ovarian carcinoma cells correlates with c-myc stimulation

1995 ◽  
Vol 61 (5) ◽  
pp. 649-657 ◽  
Author(s):  
Georg Krupitza ◽  
Wolfgang Hulla ◽  
Hanna Harant ◽  
Evelyn Dittrich ◽  
Enikö Kallay ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Ovarian Carcinoma ◽  
Carcinoma Cells ◽  
Ovarian Carcinoma Cells

Inhibition of c-myc in breast and ovarian carcinoma cells by 1,25-dihydroxyvitamin D3, retinoic acid and dexamethasone

1993 ◽  
Vol 4 (2) ◽  
pp. 201-208 ◽  
Author(s):  
D E Saunders ◽  
C Christensen ◽  
N L Wappler ◽  
J F Schultz ◽  
W D Lawrence ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Ovarian Carcinoma ◽  
Carcinoma Cells ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Ovarian Carcinoma Cells
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