Non-thermal effects of electromagnetic fields at mobile phone frequency on the refolding of an intracellular protein: Myoglobin

2004 ◽  
Vol 93 (1) ◽  
pp. 188-196 ◽  
Author(s):  
Fabrizio Mancinelli ◽  
Michele Caraglia ◽  
Alberto Abbruzzese ◽  
Guglielmo d'Ambrosio ◽  
Rita Massa ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Electromagnetic Fields ◽  
Thermal Effects ◽  
Intracellular Protein

scholarly journals Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies

2007 ◽  
Vol 405 (3) ◽  
pp. 559-568 ◽  
Author(s):  
Joseph Friedman ◽  
Sarah Kraus ◽  
Yirmi Hauptman ◽  
Yoni Schiff ◽  
Rony Seger
Keyword(s):  
Mobile Phone ◽  
Electromagnetic Fields ◽  
Mobile Phones ◽  
Egf Receptor ◽  
Nadh Oxidase ◽  
Mitogen Activated Protein Kinase ◽  
Heparin Binding ◽  
Cellular Processes ◽  
Mapk Cascades ◽  
Mitogen Activated Protein

The exposure to non-thermal microwave electromagnetic fields generated by mobile phones affects the expression of many proteins. This effect on transcription and protein stability can be mediated by the MAPK (mitogen-activated protein kinase) cascades, which serve as central signalling pathways and govern essentially all stimulated cellular processes. Indeed, long-term exposure of cells to mobile phone irradiation results in the activation of p38 as well as the ERK (extracellular-signal-regulated kinase) MAPKs. In the present study, we have studied the immediate effect of irradiation on the MAPK cascades, and found that ERKs, but not stress-related MAPKs, are rapidly activated in response to various frequencies and intensities. Using signalling inhibitors, we delineated the mechanism that is involved in this activation. We found that the first step is mediated in the plasma membrane by NADH oxidase, which rapidly generates ROS (reactive oxygen species). These ROS then directly stimulate MMPs (matrix metalloproteinases) and allow them to cleave and release Hb-EGF [heparin-binding EGF (epidermal growth factor)]. This secreted factor activates the EGF receptor, which in turn further activates the ERK cascade. Thus this study demonstrates for the first time a detailed molecular mechanism by which electromagnetic irradiation from mobile phones induces the activation of the ERK cascade and thereby induces transcription and other cellular processes.

scholarly journals CT2A Cell Viability Modulated by Electromagnetic Fields at Extremely Low Frequency under No Thermal Effects

2019 ◽  
Vol 21 (1) ◽  
pp. 152 ◽  
Author(s):  
Olga García-Minguillán ◽  
Raquel Prous ◽  
Maria del Carmen Ramirez-Castillejo ◽  
Ceferino Maestú
Keyword(s):  
Cell Viability ◽  
Frequency Dependence ◽  
Electromagnetic Fields ◽  
Thermal Effects ◽  
Low Frequency ◽  
Human Beings ◽  
Cellular Mechanisms ◽  
Low Frequencies ◽  
Hsp90 Expression

The effects produced by electromagnetic fields (EMFs) on human beings at extremely low frequencies (ELFs) have being investigated in the past years, across in vitro studies, using different cell lines. Nevertheless, the effects produced on cells are not clarified, and the cellular mechanisms and cell-signaling processes involved are still unknown. This situation has resulted in a division among the scientific community about the adequacy of the recommended level of exposure. In this sense, we consider that it is necessary to develop long-term exposure studies and check if the recommended levels of EMFs are under thermal effects. Hence, we exposed CT2A cells to different EMFs at different ELFs at short and long times. Our results showed frequency dependence in CT2A exposed during 24 h to a small EMF of 30 μT equal to those originated by the Earth and frequency dependence after the exposure during seven days to an EMF of 100 µT at different ELFs. Particularly, our results showed a remarkable cell viability decrease of CT2A cells exposed to EMFs of 30 Hz. Nevertheless, after analyzing the thermal effects in terms of HSP90 expression, we did not find thermal damages related to the differences in cell viability, so other crucial cellular mechanism should be involved.

Effects of weak mobile phone-Electromagnetic fields (GSM, UMTS) on event related potentials and cognitive functions

2008 ◽  
Vol 29 (6) ◽  
pp. 488-497 ◽  
Author(s):  
H. Kleinlogel ◽  
Th. Dierks ◽  
Th. Koenig ◽  
H. Lehmann ◽  
A. Minder ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Electromagnetic Fields ◽  
Cognitive Functions ◽  
Event Related Potentials ◽  
Related Potentials

The effect of mobile phone electromagnetic fields on the alpha rhythm of human electroencephalogram

2008 ◽  
Vol 29 (1) ◽  
pp. 1-10 ◽  
Author(s):  
R.J. Croft ◽  
D.L. Hamblin ◽  
J. Spong ◽  
A.W. Wood ◽  
R.J. McKenzie ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Electromagnetic Fields ◽  
Alpha Rhythm ◽  
Human Electroencephalogram
Sign in / Sign up

Export Citation Format

Share Document