Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2

2004 ◽  
Vol 91 (5) ◽  
pp. 865-879 ◽  
Author(s):  
Julio C. Tapia ◽  
Victor M. Bolanos-Garcia ◽  
Muhammed Sayed ◽  
Catherine C. Allende ◽  
Jorge E. Allende
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Regulatory Protein ◽  
Cell Cycle Regulatory Protein ◽  
Kinase Ck2

Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin

2004 ◽  
Vol 315 (4) ◽  
pp. 1011-1017 ◽  
Author(s):  
Monika Kulartz ◽  
Ekkehard Hiller ◽  
Ferdinand Kappes ◽  
Lorenzo A Pinna ◽  
Rolf Knippers
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Regulatory Protein ◽  
Cell Cycle Regulatory Protein ◽  
Kinase Ck2

scholarly journals Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast

FEBS Journal ◽  
2007 ◽  
Vol 274 (17) ◽  
pp. 4654-4667 ◽  
Author(s):  
Michaela Angermayr ◽  
Elisabeth Hochleitner ◽  
Friedrich Lottspeich ◽  
Wolfhard Bandlow
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Kinase Ck2

scholarly journals The regulatory β-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis

Oncogene ◽  
2008 ◽  
Vol 27 (37) ◽  
pp. 4986-4997 ◽  
Author(s):  
C W Yde ◽  
B B Olsen ◽  
D Meek ◽  
N Watanabe ◽  
B Guerra
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Cell Cycle Progression ◽  
Β Subunit ◽  
Cycle Progression ◽  
Kinase Ck2

Cell cycle dependent regulation of protein kinase CK2 signaling to the nuclear matrix

2003 ◽  
Vol 88 (4) ◽  
pp. 812-822 ◽  
Author(s):  
Huamin Wang ◽  
Shihui Yu ◽  
Alan T. Davis ◽  
Khalil Ahmed
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Nuclear Matrix ◽  
Protein Kinase Ck2 ◽  
Cycle Dependent ◽  
Kinase Ck2

Protein kinase CK2 in gene control at cell cycle entry

2005 ◽  
Vol 274 (1-2) ◽  
pp. 189-200 ◽  
Author(s):  
Walter Pyerin ◽  
Thomas Barz ◽  
Karin Ackermann
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Gene Control ◽  
Cell Cycle Entry ◽  
Kinase Ck2

scholarly journals Down-regulation of CK2α correlates with decreased expression levels of DNA replication minichromosome maintenance protein complex (MCM) genes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Susanne Schaefer ◽  
Thomas K. Doktor ◽  
Sabrina B. Frederiksen ◽  
Kathleen Chea ◽  
Mirka Hlavacova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Dna Replication ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Minichromosome Maintenance ◽  
Catalytic Subunits ◽  
Expression Levels ◽  
Kinase Ck2

Abstract Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subunits (CK2α and/or CK2α’) and two regulatory subunits (CK2β). It is implicated in every stage of the cell cycle and in the regulation of various intracellular pathways associated with health and disease states. The catalytic subunits have similar biochemical activity, however, their functions may differ significantly in cells and in vivo. In this regard, homozygous deletion of CK2α leads to embryonic lethality in mid-gestation potentially due to severely impaired cell proliferation. To determine the CK2α-dependent molecular mechanisms that control cell proliferation, we established a myoblast-derived cell line with inducible silencing of CK2α and carried out a comprehensive RNA-Seq analysis of gene expression. We report evidence that CK2α depletion causes delayed cell cycle progression through the S-phase and defective response to replication stress. Differential gene expression analysis revealed that the down-regulated genes were enriched in pathways implicated in cell cycle regulation, DNA replication and DNA damage repair. Interestingly, the genes coding for the minichromosome maintenance proteins (MCMs), which constitute the core of the replication origin recognition complex, were among the most significantly down-regulated genes. These findings were validated in cells and whole mouse embryos. Taken together, our study provides new evidence for a critical role of protein kinase CK2 in controlling DNA replication initiation and the expression levels of replicative DNA helicases, which ensure maintenance of proliferative potential and genome integrity in eukaryotic cells.

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