In vivo imaging and tumor therapy with the sodium iodide symporter

2003 ◽  
Vol 90 (6) ◽  
pp. 1079-1086 ◽  
Author(s):  
David Dingli ◽  
Stephen J. Russell ◽  
John C. Morris
Keyword(s):  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Tumor Therapy ◽  
Sodium Iodide Symporter

scholarly journals In Vivo Imaging of Retinoic Acid Receptor Activity using a Sodium/Iodide Symporter and Luciferase Dual Imaging Reporter Gene

2004 ◽  
Vol 3 (3) ◽  
pp. 153535002004041
Author(s):  
Min Kyung So ◽  
Joo Hyun Kang ◽  
June-Key Chung ◽  
Yong Jin Lee ◽  
Jae Hoon Shin ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Reporter Gene ◽  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Retinoic Acid Receptor ◽  
Receptor Activity ◽  
Sodium Iodide Symporter ◽  
Acid Receptor ◽  
Dual Imaging

scholarly journals Enhancing Expression of Functional Human Sodium Iodide Symporter and Somatostatin Receptor in Recombinant Oncolytic Vaccinia Virus for In Vivo Imaging of Tumors

2016 ◽  
Vol 58 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Jiahu Wang ◽  
Rozanne Arulanandam ◽  
Richard Wassenaar ◽  
Theresa Falls ◽  
Julia Petryk ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Somatostatin Receptor ◽  
Sodium Iodide Symporter

scholarly journals In Vivo Imaging of Retinoic Acid Receptor Activity using a Sodium/Iodide Symporter and Luciferase Dual Imaging Reporter Gene

2004 ◽  
Vol 3 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Min Kyung So ◽  
Joo Hyun Kang ◽  
June-Key Chung ◽  
Yong Jin Lee ◽  
Jae Hoon Shin ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Reporter Gene ◽  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Retinoic Acid Receptor ◽  
Receptor Activity ◽  
Sodium Iodide Symporter ◽  
Acid Receptor ◽  
Dual Imaging

scholarly journals [18F]tetrafluoroborate-PET/CT enables sensitive tumor and metastasis in vivo imaging in a sodium iodide symporter-expressing tumor model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
S. Diocou ◽  
A. Volpe ◽  
M. Jauregui-Osoro ◽  
M. Boudjemeline ◽  
K. Chuamsaamarkkee ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Tumor Model ◽  
Sodium Iodide Symporter ◽  
Pet Ct

scholarly journals In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas

Gene Therapy ◽  
2002 ◽  
Vol 9 (17) ◽  
pp. 1139-1145 ◽  
Author(s):  
J-Y Cho ◽  
D HY Shen ◽  
W Yang ◽  
B Williams ◽  
T LF Buckwalter ◽  
...  
Keyword(s):  
Animal Model ◽  
Gene Transfer ◽  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter

scholarly journals Rapid regulation of thyroid sodium–iodide symporter activity by thyrotrophin and iodine

2005 ◽  
Vol 184 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Andrea C F Ferreira ◽  
Lívia P Lima ◽  
Renata L Araújo ◽  
Glaucia Müller ◽  
Renata P Rocha ◽  
...  
Keyword(s):  
Sodium Iodide ◽  
Iodine Content ◽  
Concomitant Administration ◽  
High Serum ◽  
Sodium Iodide Symporter ◽  
Physiological Control ◽  
Iodide Uptake ◽  
Thyroid Hormone Biosynthesis ◽  
Serum Tsh

Transport of iodide into thyrocytes, a fundamental step in thyroid hormone biosynthesis, depends on the presence of the sodium–iodide symporter (NIS). The importance of the NIS for diagnosis and treatment of diseases has raised several questions about its physiological control. The goal of this study was to evaluate the influence of thyroid iodine content on NIS regulation by thyrotrophin (TSH) in vivo. We showed that 15-min thyroid radioiodine uptake can be a reliable measurement of NIS activity in vivo. The effect of TSH on the NIS was evaluated in rats treated with 1-methyl-2-mercaptoimidazole (MMI; hypothyroid with high serum TSH concentrations) for 21 days, and after 1 (R1d), 2 (R2d), or 5 (R5d) days of withdrawal of MMI. NIS activity was significantly greater in both MMI and R1d rats. In R2d and R5d groups, thyroid iodide uptake returned to normal values, despite continuing high serum TSH, possibly as a result of the re-establishment of iodine organification after withdrawal of MMI. Excess iodine (0.05% NaI for 6 days) promoted a significant reduction in thyroid radioiodide uptake, an effect that was blocked by concomitant administration of MMI, confirming previous findings that iodine organification is essential for the iodide transport blockade seen during iodine overload. Therefore, our data show that modulation of the thyroid NIS by TSH depends primarily on thyroid iodine content and, further, that the regulation of NIS activity is rapid.

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