Comparison of centrifugal and membrane filtration modalities on therapeutic plasma exchange

2022 ◽  
Author(s):  
Muzaffer Keklik ◽  
Serhat Çelik ◽  
Esra Yıldızhan
Keyword(s):  
Plasma Exchange ◽  
Membrane Filtration ◽  
Therapeutic Plasma Exchange

scholarly journals Centrifugal and Membrane Therapeutic Plasma Exchange – A Mini-review

2018 ◽  
Vol 14 (2) ◽  
pp. 105 ◽  
Author(s):  
Michiel Etienne Janssens ◽  
Stuart Wakelin ◽  
◽  
Keyword(s):  
Plasma Exchange ◽  
Membrane Filtration ◽  
Venous Access ◽  
Therapeutic Plasma Exchange ◽  
Performance Parameters ◽  
Procedure Time ◽  
Peripheral Venous Access ◽  
And Performance ◽  
Cellular Components ◽  
Comparative Information

During therapeutic plasma exchange (TPE), a large volume of a patient’s plasma is separated from the cellular components of the blood and replaced with appropriate fluids to remove circulating plasma components and disease mediators such as antibodies, cholesterol, toxins and drugs. Automated TPE systems can be categorised into two distinct groups based on the method of plasma separation: centrifugal TPE (cTPE) and membrane filtration TPE (mTPE). While technical and performance parameters for various TPE systems have been reported previously, the recent publication of several head-to-head studies directly comparing the Spectra Optia® cTPE system (Terumo BCT, Lakewood, CO, US) with mTPE systems has increased the understanding of their performance. This review summarises the comparative information between the systems. Although both device types are well tolerated, the majority of technical variables favour the cTPE system over mTPE systems, with a low risk of clotting events and benefits in plasma removal efficiency and hence procedure time. Platelet loss with the cTPE system was also shown to be similar or reduced compared with mTPE systems. Finally, flow rate requirements limit the use of peripheral venous access with mTPE devices, but not cTPE devices. Conclusively, several important differences exist between cTPE and mTPE systems that may influence treatment decisions.

Fulminant Meningococcal Sepsis: Localized Outbreak of Three Patients Treated with Therapeutic Plasma Exchange by Membrane Filtration

2010 ◽  
Vol 30 (2) ◽  
pp. 108-110 ◽  
Author(s):  
Pritesh Patel ◽  
Vinay G. Bangalore ◽  
William S. Cantwell ◽  
Sean Troxclair ◽  
Keith L. Scott ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Membrane Filtration ◽  
Therapeutic Plasma Exchange ◽  
Meningococcal Sepsis

Therapeutic Plasma Exchange Application in Children Requires Individual Decision

2020 ◽  
Author(s):  
Gürkan Atay ◽  
Demet Demirkol
Keyword(s):  
Plasma Exchange ◽  
Vascular Access ◽  
Pediatric Patients ◽  
Demyelinating Disease ◽  
Pediatric Intensive Care ◽  
Therapeutic Plasma Exchange ◽  
Transplantation Rejection ◽  
Access Problems ◽  
Uremic Syndrome

AbstractTherapeutic plasma exchange (TPE) is a treatment administered with the aim of removing a pathogenic material or compound causing morbidity in a variety of neurologic, hematologic, renal, and autoimmune diseases. In this study, we aimed to assess the indications, efficacy, reliability, complications, and treatment response of pediatric patients for TPE. This retrospective study analyzed data from 39 patients aged from 0 to 18 years who underwent a total of 172 TPE sessions from January 2015 to April 2018 in a tertiary pediatric intensive care unit. Indications for TPE were, in order of frequency, macrophage activation syndrome (28.2%, n = 11), renal transplantation rejection (15.4%, n = 6), liver failure (15.4%, n = 6), Guillain–Barre's syndrome (15%, n = 6), hemolytic uremic syndrome (7.7%, n = 3), acute demyelinating disease (7.7%, n = 3), septic shock (5.1%, n = 2), and intoxication (5.1%, n = 2). No patient had any adverse event related to the TPE during the procedure. The TPE session was ended prematurely in one patient due to insufficient vascular access and lack of blood flow (2.6%). In the long term, thrombosis due to the indwelling central catheter occurred (5.1%, n = 2). TPE appears to be an effective first-stage or supplementary treatment in a variety of diseases, may be safely used in pediatric patients, and there are significant findings that its area of use will increase. In experienced hands and when assessed carefully, it appears that the rate of adverse reactions and vascular access problems may be low enough to be negligible.

Therapeutic plasma exchange in intensive care and intensive nephrology

2018 ◽  
Vol 20 (4) ◽  
pp. 394-403
Author(s):  
M. S. Vetsheva ◽  
◽  
K.E Loss . ◽  
O.L. Podkorytova ◽  
E.V. Lebedkov ◽  
...  
Keyword(s):  
Intensive Care ◽  
Plasma Exchange ◽  
Therapeutic Plasma Exchange

Therapeutic plasma exchange in a single center: Ibni Sina experience

2004 ◽  
Vol 30 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Önder Arslan ◽  
Mutlu Arat ◽  
Ibrahim Tek ◽  
Erol Ayyildiz ◽  
Osman Ilhan
Keyword(s):  
Plasma Exchange ◽  
Therapeutic Plasma Exchange ◽  
Single Center
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