Comparison of three modalities of plasmapheresis on coagulation: Centrifugal, single‐membrane filtration, and double‐filtration plasmapheresis

2021 ◽  
Author(s):  
Raphaël Marlu ◽  
Hamza Naciri Bennani ◽  
Landry Seyve ◽  
Johan Noble ◽  
Eloi Chevallier ◽  
...  
Keyword(s):  
Membrane Filtration ◽  
Double Filtration Plasmapheresis ◽  
Single Membrane ◽  
Double Filtration

How to improve clotting factors depletion in double‐filtration plasmapheresis

2021 ◽  
Author(s):  
Hamza Naciri Bennani ◽  
Raphael Marlu ◽  
Florian Terrec ◽  
Lionel Motte ◽  
Landry Seyve ◽  
...  
Keyword(s):  
Clotting Factors ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

Double Filtration Plasmapheresis for the Treatment of Rheumatoid Arthritis: A Study of 21 Cases

2008 ◽  
Vol 21 (2) ◽  
pp. 96-98 ◽  
Author(s):  
Jing-Duo Liu ◽  
Chunjing Zhang ◽  
Wei-Sheng Li ◽  
Li-De Lun
Keyword(s):  
Rheumatoid Arthritis ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

scholarly journals Dynamics of plasma lipoproteins and lipids during double filtration plasmapheresis (DEP)

1987 ◽  
Vol 26 (2) ◽  
pp. 176-179 ◽  
Author(s):  
Shigeki SAKATA ◽  
Takashi Komaki ◽  
Noriko KOJIMA ◽  
Masafumi MATSUDA ◽  
Satoshi MAEDA ◽  
...  
Keyword(s):  
Plasma Lipoproteins ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

Treatment of homozygous patients with familial hypercholesterolemia by double-filtration plasmapheresis

1986 ◽  
Vol 61 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Hiroshi Mabuchi ◽  
Ichiro Michishita ◽  
Takeshi Sakai ◽  
Yasuyuki Sakai ◽  
Akira Watanabe ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

MO661COMPARISON OF CLINICAL EFFICACY OF CENTRIFUGAL-MEMBRANOUS DOUBLE FILTRATION PLASMAPHERESIS AND MEMBRANOUS DOUBLE FILTRATION PLASMAPHERESIS ON SEVERE LUPUS NEPHRITIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Jianhua Dong ◽  
Li Huang ◽  
Chuan Li ◽  
Ling Kong ◽  
Lixuan Huang ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Adverse Events ◽  
Blood Cell ◽  
Serum Creatinine ◽  
Clinical Efficacy ◽  
Vascular Access ◽  
Double Filtration Plasmapheresis ◽  
Severe Lupus Nephritis ◽  
Double Filtration

Abstract Background and Aims The Study delves into the clinical efficacy and advantages of centrifugal double filtration plasmapheresis on severe lupus nephritis (LN) by comparing it with membranous double filtration plasmapheresis (DFPP). Method A retrospective analysis was performed on 56 patients who were diagnosed with severe LN and had received DFPP treatment from May 2016 and January 2020. Of them, 38 were given centrifugal DFPP and had their plasma centrifuged in a blood cell separator, and 18 were given membranous DFPP and had their plasma centrifuged in an MPS07 plasma separator. An EC20W plasma component separator was used as the secondary filter to reprocess the separated plasma of all of them. The two DFPPs were compared for differences in clinical efficacy, vascular access, dosage of anticoagulant, treatment cost and adverse events in patients with severe LN. Results Of the 56 severe LN patients (including 43 females and 13 males), the median of age of onset was 29 years old, the SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) was 18.6±6.0 points and the serum creatinine was 402(294,553) umol/L, and all patients had acute kidney injury and 51 of them (91.1%) required renal replacement therapy (RRT). A total of 142 DFPPs were performed, including 97 centrifugal DFPPs and 45 membranous DFPPs. After treatment and at Month 3 of follow-up visit, patients in both the centrifugal DFPP group and the membranous DFPP group had ANA, AdsDNA titer, quantitative urinary protein, urinary red blood cell count and serum creatinine significantly dropped and hemoglobin significantly increased over those before treatment, the differences in which between the two groups, however, were not statistically significant. The centrifugal DFPP group had a more significant drop in complements C3 and C4 after treatment. Comparison of the data before and after a single DFPP treatment showed that the membranous DFPP group had a more significantly longer prothrombin time, but there were no differences in partial prothrombin time, fibrinogen and platelet change between the two groups. At Month 3 of follow-up visit, 31 of the 51 RRT patients (60.8%) (including 34 given centrifugal DFPP and 17 given membranous DFPP) were released from dialysis, including 23 given centrifugal DFPP and 8 given membranous DFPP. In the membranous DFPP group, all patients had the vascular access built via the central venous catheter, while in the centrifugal DFPP group, 6 patients (15.8%) had the vascular access built by puncturing into the artery or vein. The dosage of the anticoagulant, the low molecular weight heparin, to the centrifugal DFPP group was significantly lower than that to the membranous DFPP group (1174±243 vs 4106±399IU, P<0.001), and in the centrifugal DFPP group, 29 patients (76.3%) were given 4% citric acid alone for anti-coagulation. No blood coagulation occurred. In terms of treatment consumables, the membranous DFPP group had a significantly higher cost than the centrifugal DFPP group (RMB4340.2±237.0 vs 5677.0±0.0, P<0.001). Two patients (4.4%) in the membranous DFPP group developed skin ectasis, epistaxis or aggravated alveolar hemorrhage after treatment, and four patients (4.1%) in the centrifugal DFPP group developed perioral numbness, numbness in distal extremities or tetany during treatment, which was alleviated after calcium supplementation. Conclusion Centrifugal DFPP differed little from membranous DFPP in clinical efficacy in severe LN patients, but had lower anti-coagulation requirements, cost less on treatment consumables, and caused no severe adverse events, so it can be used as an important means to treat severe LN.

Double Filtration Plasmapheresis Can Decrease Factor XIII Activity

2007 ◽  
Vol 11 (3) ◽  
pp. 165-170 ◽  
Author(s):  
Norio Hanafusa ◽  
Yasushi Kondo ◽  
Makoto Suzuki ◽  
Akihide Nakao ◽  
Eisei Noiri ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration
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