Safety and efficacy of cryoprecipitate-poor plasma as a replacement fluid for therapeutic plasma exchange in thrombotic thrombocytopenic purpura: A single center retrospective evaluation

2014 ◽  
Vol 29 (6) ◽  
pp. 311-315 ◽  
Author(s):  
Bianca Stefanello ◽  
Erich Vinícius De Paula ◽  
Fernanda Andrade Orsi ◽  
Jose Francisco Comenalli Marques ◽  
Eduardo Gasparotto Roveri ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Therapeutic Plasma Exchange ◽  
Retrospective Evaluation ◽  
Single Center ◽  
Thrombocytopenic Purpura ◽  
Safety And Efficacy ◽  
Replacement Fluid

scholarly journals Combination of Fresh Frozen Plasma and Cryosupernatant Plasma for Therapeutic Plasma Exchange in Thrombotic Thrombocytopenic Purpura: A Single Institution Experience

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Qiuyan Lin ◽  
Liping Fan ◽  
Haobo Huang ◽  
Feng Zeng ◽  
Danhui Fu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Fresh Frozen Plasma ◽  
Therapeutic Plasma Exchange ◽  
Dominant Group ◽  
Thrombocytopenic Purpura ◽  
Replacement Fluid ◽  
Fresh Frozen ◽  
Frozen Plasma

Purpose. To evaluate the impact of a combination of fresh frozen plasma (FFP) and cryosupernatant plasma (CP) as a replacement fluid in therapeutic plasma exchange (TPE) on early therapeutic response and long-term survival of patients with thrombotic thrombocytopenic purpura (TTP). Materials and Methods. A total of 44 patients with suspected TTP were screened by Bentley and PLASMIC scores. Twenty-seven patients treated with TPE using the FFP and CP combination as the replacement fluid were enrolled and divided into two groups: 11 patients who received TPE with CP-dominant replacement fluid (FFP/CP<1) and 16 patients who received TPE with FFP-dominant replacement fluid (FFP/CP>1). Results. There were no significant differences in the demographic and clinicopathological characteristics between the two groups except for the international normalized ratio (INR). The number of TPE procedures was lower, and time to achieve complete response was shorter in the CP-dominant group than in the FFP-dominant group. There were no significant differences in overall survival between the two groups. Conclusion. The CP-dominant replacement fluid was superior to the FFP-dominant replacement fluid in early response to TPE in patients with TTP, but did not impact the patients’ overall survival.

Cryosupernatant as replacement fluid for plasma exchange in thrombotic thrombocytopenic purpura

1996 ◽  
Vol 94 (2) ◽  
pp. 383-386 ◽  
Author(s):  
G. ROCK ◽  
KENNETH H. SHUMAK ◽  
DAVID M. C. SUTTON ◽  
NOEL A. BUSKARD ◽  
RAMA C. NAIR
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Replacement Fluid

Effect of therapeutic plasma exchange on plasma levels of oxidative biomarkers in a patient with thrombotic thrombocytopenic purpura

2014 ◽  
Vol 94 (4) ◽  
pp. 368-373 ◽  
Author(s):  
Sebastiano Gangemi ◽  
Alessandro Allegra ◽  
Paolo Sciarrone ◽  
Sabina Russo ◽  
Mariateresa Cristani ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Plasma Levels ◽  
Therapeutic Plasma Exchange ◽  
Thrombocytopenic Purpura ◽  
Oxidative Biomarkers
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