Inhibition of lecithin:Cholesterol acyltransferase activity in human blood plasma by cigarette smoke extract and reactive aldehydes

1995 ◽  
Vol 10 (3) ◽  
pp. 121-128 ◽  
Author(s):  
Chen Chen ◽  
George Loo
Keyword(s):  
Blood Plasma ◽  
Cigarette Smoke ◽  
Human Blood ◽  
Cigarette Smoke Extract ◽  
Human Blood Plasma ◽  
Lecithin:Cholesterol Acyltransferase ◽  
Acyltransferase Activity ◽  
Reactive Aldehydes

scholarly journals Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid

1991 ◽  
Vol 277 (1) ◽  
pp. 133-138 ◽  
Author(s):  
B Frei ◽  
T M Forte ◽  
B N Ames ◽  
C E Cross
Keyword(s):  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Blood Plasma ◽  
Gas Phase ◽  
Cigarette Smoke ◽  
Human Blood ◽  
Biological Fluids ◽  
Human Blood Plasma ◽  
Lipid Hydroperoxides ◽  
Protein Thiols

Cigarette smoke (CS) is known to contain a large number of oxidants. In order to assess the oxidative effects of CS on biological fluids, we exposed human blood plasma to filtered (gas phase) and unfiltered (whole) CS, and determined the rate of utilization of endogenous antioxidants in relation to the appearance of lipid hydroperoxides. Lipid peroxidation was measured with a specific and sensitive assay that can detect lipid hydroperoxides at plasma levels as low as 10 nM. We found that exposure of plasma to the gas phase of CS, but not to whole CS, induces lipid peroxidation once endogenous ascorbic acid has been oxidized completely. In addition, CS exposure caused oxidation of plasma protein thiols and albumin-bound bilirubin, whereas uric acid and alpha-tocopherol were not consumed at significant rates. In plasma exposed to the gas phase of CS, low-density lipoprotein exhibited slightly increased electrophoretic mobility, but there was no apparent degradation of apolipoprotein B. Our results support the concept of an increased vitamin C utilization in smokers, and suggest that lipid peroxidation induced by oxidants present in the gas phase of CS leads to potentially atherogenic changes in lipoproteins.

Dual Layer Mixed Matrix Hollow Fiber Membranes for Outside-In Filtration of Human Blood Plasma

2020 ◽  
Author(s):  
O.E.M. ter Beek ◽  
M.K. van Gelder ◽  
C. Lokhorst ◽  
D.H.M. Hazenbrink ◽  
B.H. Lentferink ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Hollow Fiber ◽  
Human Blood Plasma ◽  
Hollow Fiber Membranes ◽  
Mixed Matrix ◽  
Fiber Membranes

scholarly journals Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma

2002 ◽  
Vol 43 (3) ◽  
pp. 365-374
Author(s):  
Elisa Campos ◽  
Leila Kotite ◽  
Patricia Blanche ◽  
Yasushi Mitsugi ◽  
Philip H. Frost ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Human Blood Plasma ◽  
Particle Fraction

Amino acid sequence of the sex steroid binding protein of human blood plasma

Biochemistry ◽  
1986 ◽  
Vol 25 (23) ◽  
pp. 7584-7590 ◽  
Author(s):  
Kenneth A. Walsh ◽  
Koiti Titani ◽  
Koji Takio ◽  
Santosh Kumar ◽  
Rutherford Hayes ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Blood Plasma ◽  
Human Blood ◽  
Binding Protein ◽  
Sex Steroid ◽  
Human Blood Plasma ◽  
Steroid Binding ◽  
Steroid Binding Protein
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